IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v11y2020i1d10.1038_s41467-019-13901-z.html
   My bibliography  Save this article

Clinically accurate diagnosis of Alzheimer’s disease via multiplexed sensing of core biomarkers in human plasma

Author

Listed:
  • Kayoung Kim

    (Korea Advanced Institute of Science and Technology (KAIST))

  • Min-Ji Kim

    (Korea Advanced Institute of Science and Technology (KAIST))

  • Da Won Kim

    (Korea Advanced Institute of Science and Technology (KAIST))

  • Su Yeong Kim

    (Korea Advanced Institute of Science and Technology (KAIST))

  • Steve Park

    (Korea Advanced Institute of Science and Technology (KAIST))

  • Chan Beum Park

    (Korea Advanced Institute of Science and Technology (KAIST))

Abstract

Alzheimer’s disease (AD) is the most prevalent neurodegenerative disorder, affecting one in ten people aged over 65 years. Despite the severity of the disease, early diagnosis of AD is still challenging due to the low accuracy or high cost of neuropsychological tests and neuroimaging. Here we report clinically accurate and ultrasensitive detection of multiple AD core biomarkers (t-tau, p-tau181, Aβ42, and Aβ40) in human plasma using densely aligned carbon nanotubes (CNTs). The closely packed and unidirectionally aligned CNT sensor array exhibits high precision, sensitivity, and accuracy, evidenced by a low coefficient of variation ( 93.0%). By measuring the levels of t-tau/Aβ42, p-tau181/Aβ42, and Aβ42/Aβ40 in clinical blood samples, the sensor array successfully discriminates the clinically diagnosed AD patients from healthy controls with an average sensitivity of 90.0%, a selectivity of 90.0%, and an average accuracy of 88.6%.

Suggested Citation

  • Kayoung Kim & Min-Ji Kim & Da Won Kim & Su Yeong Kim & Steve Park & Chan Beum Park, 2020. "Clinically accurate diagnosis of Alzheimer’s disease via multiplexed sensing of core biomarkers in human plasma," Nature Communications, Nature, vol. 11(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-019-13901-z
    DOI: 10.1038/s41467-019-13901-z
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-019-13901-z
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-019-13901-z?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Sojeong Lee & Eunjung Kim & Chae-Eun Moon & Chaewon Park & Jong-Woo Lim & Minseok Baek & Moo-Kwang Shin & Jisun Ki & Hanna Cho & Yong Woo Ji & Seungjoo Haam, 2023. "Amplified fluorogenic immunoassay for early diagnosis and monitoring of Alzheimer’s disease from tear fluid," Nature Communications, Nature, vol. 14(1), pages 1-15, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-019-13901-z. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.