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The Mouse Gut Microbial Biobank expands the coverage of cultured bacteria

Author

Listed:
  • Chang Liu

    (Institute of Microbiology, Chinese Academy of Sciences
    Chinese Academy of Sciences)

  • Nan Zhou

    (Institute of Microbiology, Chinese Academy of Sciences
    Chinese Academy of Sciences)

  • Meng-Xuan Du

    (Institute of Microbiology, Chinese Academy of Sciences)

  • Yu-Tong Sun

    (Institute of Microbiology, Chinese Academy of Sciences)

  • Kai Wang

    (University of Chinese Academy of Sciences
    Chinese Academy of Sciences)

  • Yu-Jing Wang

    (Institute of Microbiology, Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Dan-Hua Li

    (Institute of Microbiology, Chinese Academy of Sciences)

  • Hai-Ying Yu

    (Institute of Microbiology, Chinese Academy of Sciences)

  • Yuqin Song

    (Institute of Microbiology, Chinese Academy of Sciences
    Chinese Academy of Sciences)

  • Bing-Bing Bai

    (Chinese Academy of Sciences)

  • Yuhua Xin

    (Chinese Academy of Sciences)

  • Linhuan Wu

    (Chinese Academy of Sciences)

  • Cheng-Ying Jiang

    (Institute of Microbiology, Chinese Academy of Sciences
    Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Jie Feng

    (Institute of Microbiology, Chinese Academy of Sciences
    Chinese Academy of Sciences)

  • Hua Xiang

    (Institute of Microbiology, Chinese Academy of Sciences)

  • Yuguang Zhou

    (Chinese Academy of Sciences)

  • Juncai Ma

    (Chinese Academy of Sciences)

  • Jun Wang

    (University of Chinese Academy of Sciences
    Chinese Academy of Sciences)

  • Hong-Wei Liu

    (University of Chinese Academy of Sciences
    Chinese Academy of Sciences)

  • Shuang-Jiang Liu

    (Institute of Microbiology, Chinese Academy of Sciences
    Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

Abstract

Mice are widely used as experimental models for gut microbiome (GM) studies, yet the majority of mouse GM members remain uncharacterized. Here, we report the construction of a mouse gut microbial biobank (mGMB) that contains 126 species, represented by 244 strains that have been deposited in the China General Microorganism Culture Collection. We sequence and phenotypically characterize 77 potential new species and propose their nomenclatures. The mGMB includes 22 and 17 species that are significantly enriched in ob/ob and wild-type C57BL/6J mouse cecal samples, respectively. The genomes of the 126 species in the mGMB cover 52% of the metagenomic nonredundant gene catalog (sequence identity ≥ 60%) and represent 93–95% of the KEGG-Orthology-annotated functions of the sampled mouse GMs. The microbial and genome data assembled in the mGMB enlarges the taxonomic characterization of mouse GMs and represents a useful resource for studies of host-microbe interactions and of GM functions associated with host health and diseases.

Suggested Citation

  • Chang Liu & Nan Zhou & Meng-Xuan Du & Yu-Tong Sun & Kai Wang & Yu-Jing Wang & Dan-Hua Li & Hai-Ying Yu & Yuqin Song & Bing-Bing Bai & Yuhua Xin & Linhuan Wu & Cheng-Ying Jiang & Jie Feng & Hua Xiang &, 2020. "The Mouse Gut Microbial Biobank expands the coverage of cultured bacteria," Nature Communications, Nature, vol. 11(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-019-13836-5
    DOI: 10.1038/s41467-019-13836-5
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