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The upper-airway microbiota and loss of asthma control among asthmatic children

Author

Listed:
  • Yanjiao Zhou

    (University of Connecticut
    The Jackson Laboratory for Genomic Medicine)

  • Daniel Jackson

    (University of Wisconsin School of Medicine and Public Health)

  • Leonard B. Bacharier

    (Washington University School of Medicine)

  • David Mauger

    (Penn State University)

  • Homer Boushey

    (University of California)

  • Mario Castro

    (Washington University School of Medicine)

  • Juliana Durack

    (University of California)

  • Yvonne Huang

    (University of Michigan)

  • Robert F. Lemanske

    (University of Wisconsin School of Medicine and Public Health)

  • Gregory A. Storch

    (Washington University School of Medicine)

  • George M. Weinstock

    (The Jackson Laboratory for Genomic Medicine)

  • Kristine Wylie

    (Washington University School of Medicine)

  • Ronina Covar

    (National Jewish Health)

  • Anne M. Fitzpatrick

    (Emory University)

  • Wanda Phipatanakul

    (Harvard Medical School)

  • Rachel G. Robison

    (Ann and Robert H Lurie Children’s Hospital of Chicago)

  • Avraham Beigelman

    (Washington University School of Medicine
    Tel Aviv University)

Abstract

The airway microbiome has an important role in asthma pathophysiology. However, little is known on the relationships between the airway microbiome of asthmatic children, loss of asthma control, and severe exacerbations. Here we report that the microbiota’s dynamic patterns and compositions are related to asthma exacerbations. We collected nasal blow samples (n = 319) longitudinally during a clinical trial at 2 time-points within one year: randomization when asthma is under control, and at time of early loss of asthma control (yellow zone (YZ)). We report that participants whose microbiota was dominated by the commensal Corynebacterium + Dolosigranulum cluster at RD experience the lowest rates of YZs (p = 0.005) and have longer time to develop at least 2 episodes of YZ (p = 0.03). The airway microbiota have changed from randomization to YZ. A switch from the Corynebacterium + Dolosigranulum cluster at randomization to the Moraxella- cluster at YZ poses the highest risk of severe asthma exacerbation (p = 0.04). Corynebacterium’s relative abundance at YZ is inversely associated with severe exacerbation (p = 0.002).

Suggested Citation

  • Yanjiao Zhou & Daniel Jackson & Leonard B. Bacharier & David Mauger & Homer Boushey & Mario Castro & Juliana Durack & Yvonne Huang & Robert F. Lemanske & Gregory A. Storch & George M. Weinstock & Kris, 2019. "The upper-airway microbiota and loss of asthma control among asthmatic children," Nature Communications, Nature, vol. 10(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-13698-x
    DOI: 10.1038/s41467-019-13698-x
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