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Chaperone biomarkers of lifespan and penetrance track the dosages of many other proteins

Author

Listed:
  • Nikolay Burnaevskiy

    (University of Washington)

  • Bryan Sands

    (University of Washington)

  • Soo Yun

    (University of Washington)

  • Patricia M. Tedesco

    (University of Colorado)

  • Thomas E. Johnson

    (University of Colorado)

  • Matt Kaeberlein

    (University of Washington)

  • Roger Brent

    (Fred Hutchinson Cancer Research Center)

  • Alexander Mendenhall

    (University of Washington)

Abstract

Many traits vary among isogenic individuals in homogeneous environments. In microbes, plants and animals, variation in the protein chaperone system affects many such traits. In the animal model C. elegans, the expression level of hsp-16.2 chaperone biomarkers correlates with or predicts the penetrance of mutations and lifespan after heat shock. But the physiological mechanisms causing cells to express different amounts of the biomarker were unknown. Here, we used an in vivo microscopy approach to dissect different contributions to cell-to-cell variation in hsp-16.2 expression in the intestines of young adult animals, which generate the most lifespan predicting signal. While we detected both cell autonomous intrinsic noise and signaling noise, we found both contributions were relatively unimportant. The major contributor to cell-to-cell variation in biomarker expression was general differences in protein dosage. The hsp-16.2 biomarker reveals states of high or low effective dosage for many genes.

Suggested Citation

  • Nikolay Burnaevskiy & Bryan Sands & Soo Yun & Patricia M. Tedesco & Thomas E. Johnson & Matt Kaeberlein & Roger Brent & Alexander Mendenhall, 2019. "Chaperone biomarkers of lifespan and penetrance track the dosages of many other proteins," Nature Communications, Nature, vol. 10(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-13664-7
    DOI: 10.1038/s41467-019-13664-7
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    Cited by:

    1. Bryan Sands & Soo Yun & Alexander R. Mendenhall, 2021. "Introns control stochastic allele expression bias," Nature Communications, Nature, vol. 12(1), pages 1-14, December.
    2. Klement Stojanovski & Helge Großhans & Benjamin D. Towbin, 2022. "Coupling of growth rate and developmental tempo reduces body size heterogeneity in C. elegans," Nature Communications, Nature, vol. 13(1), pages 1-14, December.

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