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Metabolic balancing by miR-276 shapes the mosquito reproductive cycle and Plasmodium falciparum development

Author

Listed:
  • Lena Lampe

    (Vector Biology Unit, Max Planck Institute for Infection Biology
    Francis Crick Institute)

  • Marius Jentzsch

    (Vector Biology Unit, Max Planck Institute for Infection Biology)

  • Sylwia Kierszniowska

    (metaSysX GmbH)

  • Elena A. Levashina

    (Vector Biology Unit, Max Planck Institute for Infection Biology)

Abstract

The blood-feeding behavior of Anopheles females delivers essential nutrients for egg development and drives parasite transmission between humans. Plasmodium growth is adapted to the vector reproductive cycle, but how changes in the reproductive cycle impact parasite development remains unclear. Here, we show that the bloodmeal-induced miR-276-5p fine-tunes the expression of branched-chain amino acid transferase to terminate the reproductive cycle. Silencing of miR-276 prolongs high rates of amino acid (AA) catabolism and increases female fertility, suggesting that timely termination of AA catabolism restricts mosquito investment into reproduction. Prolongation of AA catabolism in P. falciparum-infected females also compromises the development of the transmissible sporozoite forms. Our results suggest that Plasmodium sporogony exploits the surplus mosquito resources available after reproductive investment and demonstrate the crucial role of the mosquito AA metabolism in within-vector parasite proliferation and malaria transmission.

Suggested Citation

  • Lena Lampe & Marius Jentzsch & Sylwia Kierszniowska & Elena A. Levashina, 2019. "Metabolic balancing by miR-276 shapes the mosquito reproductive cycle and Plasmodium falciparum development," Nature Communications, Nature, vol. 10(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-13627-y
    DOI: 10.1038/s41467-019-13627-y
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    Cited by:

    1. Paola Carrillo-Bustamante & Giulia Costa & Lena Lampe & Elena A. Levashina, 2023. "Evolutionary modelling indicates that mosquito metabolism shapes the life-history strategies of Plasmodium parasites," Nature Communications, Nature, vol. 14(1), pages 1-13, December.

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