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Maternal vaccination and protective immunity against Zika virus vertical transmission

Author

Listed:
  • Chao Shan

    (University of Texas Medical Branch
    Wuhan National Biosafety Laboratory, Mega-Science Center for Bio-Safety Research, Chinese Academy of Sciences)

  • Xuping Xie

    (University of Texas Medical Branch)

  • Huanle Luo

    (University of Texas Medical Branch)

  • Antonio E. Muruato

    (University of Texas Medical Branch)

  • Yang Liu

    (University of Texas Medical Branch)

  • Maki Wakamiya

    (University of Texas Medical Branch)

  • Jun-Ho La

    (University of Texas Medical Branch)

  • Jin Mo Chung

    (University of Texas Medical Branch)

  • Scott C. Weaver

    (University of Texas Medical Branch
    University of Texas Medical Branch
    University of Texas Medical Branch
    University of Texas Medical Branch)

  • Tian Wang

    (University of Texas Medical Branch
    University of Texas Medical Branch
    University of Texas Medical Branch)

  • Pei-Yong Shi

    (University of Texas Medical Branch
    University of Texas Medical Branch
    University of Texas Medical Branch
    University of Texas Medical Branch)

Abstract

An important goal of the Zika virus (ZIKV) vaccine is to prevent a congenital syndrome in fetuses of pregnant women, but studies directly evaluating maternal vaccination for ZIKV are lacking. Here we report maternal vaccination using a live-attenuated ZIKV vaccine (3ʹUTR-∆10-LAV) in a pregnant mouse model. Maternal immunization with 3ʹUTR-∆10-LAV does not cause any adverse effects on pregnancy, fetal development, or offspring behavior. One maternal immunization fully protects dams against ZIKV infection and in utero transmission. Although neutralizing antibody alone is sufficient to prevent in utero transmission, a higher neutralizing titer is required to protect pregnant mice against in utero transmission than that required to protect non-pregnant mice against viral infection. The immunized dams transfer maternal antibodies to pups, which protect neonates against ZIKV infection. Notably, pregnancy weakens maternal T cell response to 3ʹUTR-∆10-LAV vaccination. Our results suggest that, besides vaccinating non-pregnant individuals, 3ʹUTR-∆10-LAV may also be considered for maternal vaccination.

Suggested Citation

  • Chao Shan & Xuping Xie & Huanle Luo & Antonio E. Muruato & Yang Liu & Maki Wakamiya & Jun-Ho La & Jin Mo Chung & Scott C. Weaver & Tian Wang & Pei-Yong Shi, 2019. "Maternal vaccination and protective immunity against Zika virus vertical transmission," Nature Communications, Nature, vol. 10(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-13589-1
    DOI: 10.1038/s41467-019-13589-1
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    Cited by:

    1. Youssouf Sereme & Cécile Schrimp & Helène Faury & Maeva Agapoff & Esther Lefebvre-Wloszczowski & Yunhua Chang Marchand & Elisabeth Ageron-Ardila & Emilie Panafieu & Frank Blec & Mathieu Coureuil & Eri, 2024. "A live attenuated vaccine to prevent severe neonatal Escherichia coli K1 infections," Nature Communications, Nature, vol. 15(1), pages 1-16, December.

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