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DNA origami cryptography for secure communication

Author

Listed:
  • Yinan Zhang

    (Shanghai Jiao Tong University
    Shanghai Institute of Applied Physics, Chinese Academy of Sciences)

  • Fei Wang

    (Shanghai Jiao Tong University)

  • Jie Chao

    (Nanjing University of Posts & Telecommunications)

  • Mo Xie

    (Shanghai Institute of Applied Physics, Chinese Academy of Sciences)

  • Huajie Liu

    (Tongji University)

  • Muchen Pan

    (Shanghai Institute of Applied Physics, Chinese Academy of Sciences)

  • Enzo Kopperger

    (Technische Universität München)

  • Xiaoguo Liu

    (Shanghai Jiao Tong University)

  • Qian Li

    (Shanghai Jiao Tong University)

  • Jiye Shi

    (Shanghai Institute of Applied Physics, Chinese Academy of Sciences)

  • Lihua Wang

    (Shanghai Institute of Applied Physics, Chinese Academy of Sciences
    East China Normal University)

  • Jun Hu

    (Shanghai Institute of Applied Physics, Chinese Academy of Sciences
    Shanghai Advanced Research Institute, Chinese Academy of Sciences)

  • Lianhui Wang

    (Nanjing University of Posts & Telecommunications)

  • Friedrich C. Simmel

    (Technische Universität München)

  • Chunhai Fan

    (Shanghai Jiao Tong University)

Abstract

Biomolecular cryptography exploiting specific biomolecular interactions for data encryption represents a unique approach for information security. However, constructing protocols based on biomolecular reactions to guarantee confidentiality, integrity and availability (CIA) of information remains a challenge. Here we develop DNA origami cryptography (DOC) that exploits folding of a M13 viral scaffold into nanometer-scale self-assembled braille-like patterns for secure communication, which can create a key with a size of over 700 bits. The intrinsic nanoscale addressability of DNA origami additionally allows for protein binding-based steganography, which further protects message confidentiality in DOC. The integrity of a transmitted message can be ensured by establishing specific linkages between several DNA origamis carrying parts of the message. The versatility of DOC is further demonstrated by transmitting various data formats including text, musical notes and images, supporting its great potential for meeting the rapidly increasing CIA demands of next-generation cryptography.

Suggested Citation

  • Yinan Zhang & Fei Wang & Jie Chao & Mo Xie & Huajie Liu & Muchen Pan & Enzo Kopperger & Xiaoguo Liu & Qian Li & Jiye Shi & Lihua Wang & Jun Hu & Lianhui Wang & Friedrich C. Simmel & Chunhai Fan, 2019. "DNA origami cryptography for secure communication," Nature Communications, Nature, vol. 10(1), pages 1-8, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-13517-3
    DOI: 10.1038/s41467-019-13517-3
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    Cited by:

    1. Van der Borght, Kim & Milian Gómez, Jorge Freddy, 2024. "Public and common interest in sustainable contract farming," World Development Perspectives, Elsevier, vol. 33(C).
    2. Fligg, Robert A. & Ballantyne, Brian & Robinson, Derek T., 2022. "Informality within Indigenous land management: A land-use study at Curve Lake First Nation, Canada," Land Use Policy, Elsevier, vol. 112(C).
    3. Linlin Tang & Zhijin Tian & Jin Cheng & Yijing Zhang & Yongxiu Song & Yan Liu & Jinghao Wang & Pengfei Zhang & Yonggang Ke & Friedrich C. Simmel & Jie Song, 2023. "Circular single-stranded DNA as switchable vector for gene expression in mammalian cells," Nature Communications, Nature, vol. 14(1), pages 1-14, December.

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