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Primary decidual zone formation requires Scribble for pregnancy success in mice

Author

Listed:
  • Jia Yuan

    (Cincinnati Children’s Hospital Medical Center
    University of Cincinnati)

  • Shizu Aikawa

    (Cincinnati Children’s Hospital Medical Center
    University of Cincinnati)

  • Wenbo Deng

    (Cincinnati Children’s Hospital Medical Center
    University of Cincinnati
    Xiamen University)

  • Amanda Bartos

    (Cincinnati Children’s Hospital Medical Center
    University of Cincinnati)

  • Gerd Walz

    (University of Freiburg)

  • Florian Grahammer

    (University Medical Center Hamburg-Eppendorf)

  • Tobias B. Huber

    (University Medical Center Hamburg-Eppendorf)

  • Xiaofei Sun

    (Cincinnati Children’s Hospital Medical Center
    University of Cincinnati)

  • Sudhansu K. Dey

    (Cincinnati Children’s Hospital Medical Center
    University of Cincinnati)

Abstract

Scribble (Scrib) is a scaffold protein with multifunctional roles in PCP, tight junction and Hippo signaling. This study shows that Scrib is expressed in stromal cells around the implantation chamber following implantation. Stromal cells transform into epithelial-like cells to form the avascular primary decidual zone (PDZ) around the implantation chamber (crypt). The PDZ creates a permeability barrier around the crypt restricting immune cells and harmful agents from maternal circulation to protect embryonic health. The mechanism underlying PDZ formation is not yet known. We found that uterine deletion of Scrib by a Pgr-Cre driver leads to defective PDZ formation and implantation chamber (crypt) formation, compromising pregnancy success. Interestingly, epithelial-specific Scrib deletion by a lactoferrin-Cre (Ltf-Cre) driver does not adversely affect PDZ formation and pregnancy success. These findings provide evidence for a previously unknown function of stromal Scrib in PDZ formation, potentially involving ZO-1 and Hippo signaling.

Suggested Citation

  • Jia Yuan & Shizu Aikawa & Wenbo Deng & Amanda Bartos & Gerd Walz & Florian Grahammer & Tobias B. Huber & Xiaofei Sun & Sudhansu K. Dey, 2019. "Primary decidual zone formation requires Scribble for pregnancy success in mice," Nature Communications, Nature, vol. 10(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-13489-4
    DOI: 10.1038/s41467-019-13489-4
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    Cited by:

    1. Mengying Liu & Wenbo Deng & Lu Tang & Meng Liu & Haili Bao & Chuanhui Guo & Changxian Zhang & Jinhua Lu & Haibin Wang & Zhongxian Lu & Shuangbo Kong, 2022. "Menin directs regionalized decidual transformation through epigenetically setting PTX3 to balance FGF and BMP signaling," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    2. Sangappa B. Chadchan & Pooja Popli & Zian Liao & Eryk Andreas & Michelle Dias & Tianyuan Wang & Stephanie J. Gunderson & Patricia T. Jimenez & Denise G. Lanza & Rainer B. Lanz & Charles E. Foulds & Di, 2024. "A GREB1-steroid receptor feedforward mechanism governs differential GREB1 action in endometrial function and endometriosis," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

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