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An interhemispheric neural circuit allowing binocular integration in the optic tectum

Author

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  • Christoph Gebhardt

    (PSL Research University, INSERM U934, CNRS UMR3215)

  • Thomas O. Auer

    (PSL Research University, INSERM U934, CNRS UMR3215)

  • Pedro M. Henriques

    (University College London)

  • Gokul Rajan

    (PSL Research University, INSERM U934, CNRS UMR3215
    Sorbonne Université, INSERM, CNRS, Institut de la Vision)

  • Karine Duroure

    (PSL Research University, INSERM U934, CNRS UMR3215
    Sorbonne Université, INSERM, CNRS, Institut de la Vision)

  • Isaac H. Bianco

    (University College London)

  • Filippo Del Bene

    (PSL Research University, INSERM U934, CNRS UMR3215
    Sorbonne Université, INSERM, CNRS, Institut de la Vision)

Abstract

Binocular stereopsis requires the convergence of visual information from corresponding points in visual space seen by two different lines of sight. This may be achieved by superposition of retinal input from each eye onto the same downstream neurons via ipsi- and contralaterally projecting optic nerve fibers. Zebrafish larvae can perceive binocular cues during prey hunting but have exclusively contralateral retinotectal projections. Here we report brain activity in the tectal neuropil ipsilateral to the visually stimulated eye, despite the absence of ipsilateral retinotectal projections. This activity colocalizes with arbors of commissural neurons, termed intertectal neurons (ITNs), that connect the tectal hemispheres. ITNs are GABAergic, establish tectal synapses bilaterally and respond to small moving stimuli. ITN-ablation impairs capture swim initiation when prey is positioned in the binocular strike zone. We propose an intertectal circuit that controls execution of the prey-capture motor program following binocular localization of prey, without requiring ipsilateral retinotectal projections.

Suggested Citation

  • Christoph Gebhardt & Thomas O. Auer & Pedro M. Henriques & Gokul Rajan & Karine Duroure & Isaac H. Bianco & Filippo Del Bene, 2019. "An interhemispheric neural circuit allowing binocular integration in the optic tectum," Nature Communications, Nature, vol. 10(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-13484-9
    DOI: 10.1038/s41467-019-13484-9
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    Cited by:

    1. Giulia Fasano & Valentina Muto & Francesca Clementina Radio & Martina Venditti & Niloufar Mosaddeghzadeh & Simona Coppola & Graziamaria Paradisi & Erika Zara & Farhad Bazgir & Alban Ziegler & Giovanni, 2022. "Dominant ARF3 variants disrupt Golgi integrity and cause a neurodevelopmental disorder recapitulated in zebrafish," Nature Communications, Nature, vol. 13(1), pages 1-29, December.

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