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Simultaneous multi-signal quantification for highly precise serodiagnosis utilizing a rationally constructed platform

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  • Yuxin Liu

    (Capital Normal University)

  • Zheng Wei

    (Capital Normal University)

  • Jing Zhou

    (Capital Normal University)

  • Zhanfang Ma

    (Capital Normal University)

Abstract

Serodiagnosis with a single quantification method suffers from high false positive/negative rates. In this study, a three-channel platform with an accessional instrumented system was constructed for simultaneous electrochemical, luminescent, and photothermal quantification of H2S, a bio-indicator for acute pancreatitis (AP) diagnosis. Utilizing the specific reaction between platform and H2S, the three-channel platform showed high sensitivity and selectivity in the biological H2S concentration range. The three-channel platform was also feasible for identifying the difference in the plasma H2S concentrations of AP and normal mice. More importantly, the precision of AP serodiagnosis was significantly improved (>99.0%) using the three-signal method based on the three-channel platform and an optimized threshold, which was clearly higher than that of the single- or two-signal methods (79.5%–94.1%). Our study highlights the importance of constructing a multichannel platform for the simultaneous multi-signal quantification of bio-indicators, and provides rigorous ways to improve the precision of medical serodiagnosis.

Suggested Citation

  • Yuxin Liu & Zheng Wei & Jing Zhou & Zhanfang Ma, 2019. "Simultaneous multi-signal quantification for highly precise serodiagnosis utilizing a rationally constructed platform," Nature Communications, Nature, vol. 10(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-13358-0
    DOI: 10.1038/s41467-019-13358-0
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