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Integrated exome and RNA sequencing of dedifferentiated liposarcoma

Author

Listed:
  • Makoto Hirata

    (University of Tokyo)

  • Naofumi Asano

    (National Cancer Center Research Institute
    Keio University School of Medicine)

  • Kotoe Katayama

    (University of Tokyo)

  • Akihiko Yoshida

    (National Cancer Center Hospital)

  • Yusuke Tsuda

    (University of Tokyo
    University of Tokyo)

  • Masaya Sekimizu

    (National Cancer Center Research Institute)

  • Sachiyo Mitani

    (National Cancer Center Research Institute)

  • Eisuke Kobayashi

    (National Cancer Center Hospital)

  • Motokiyo Komiyama

    (National Cancer Center Hospital)

  • Hiroyuki Fujimoto

    (National Cancer Center Hospital)

  • Takahiro Goto

    (Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital)

  • Yukihide Iwamoto

    (Kyushu University
    Kyushu Rosai Hospital)

  • Norifumi Naka

    (Osaka International Cancer Institute)

  • Shintaro Iwata

    (National Cancer Center Hospital
    Chiba Cancer Center)

  • Yoshihiro Nishida

    (Nagoya University Graduate School of Medicine)

  • Toru Hiruma

    (Kanagawa Cancer Center)

  • Hiroaki Hiraga

    (National Hospital Organization Hokkaido Cancer Center)

  • Hirotaka Kawano

    (University of Tokyo
    Teikyo University School of Medicine)

  • Toru Motoi

    (Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital)

  • Yoshinao Oda

    (Kyushu University)

  • Daisuke Matsubara

    (Jichi Medical University)

  • Masashi Fujita

    (RIKEN Center for Integrative Medical Sciences)

  • Tatsuhiro Shibata

    (University of Tokyo)

  • Hidewaki Nakagawa

    (RIKEN Center for Integrative Medical Sciences)

  • Robert Nakayama

    (Keio University School of Medicine)

  • Tadashi Kondo

    (National Cancer Center Research Institute)

  • Seiya Imoto

    (University of Tokyo)

  • Satoru Miyano

    (University of Tokyo)

  • Akira Kawai

    (National Cancer Center Hospital)

  • Rui Yamaguchi

    (University of Tokyo)

  • Hitoshi Ichikawa

    (National Cancer Center Research Institute
    National Cancer Center-Exploratory Oncology Research & Clinical Trial Center)

  • Koichi Matsuda

    (University of Tokyo)

Abstract

The genomic characteristics of dedifferentiated liposarcoma (DDLPS) that are associated with clinical features remain to be identified. Here, we conduct integrated whole exome and RNA sequencing analysis in 115 DDLPS tumors and perform comparative genomic analysis of well-differentiated and dedifferentiated components from eight DDLPS samples. Several somatic copy-number alterations (SCNAs), including the gain of 12q15, are identified as frequent genomic alterations. CTDSP1/2-DNM3OS fusion genes are identified in a subset of DDLPS tumors. Based on the association of SCNAs with clinical features, the DDLPS tumors are clustered into three groups. This clustering can predict the clinical outcome independently. The comparative analysis between well-differentiated and dedifferentiated components identify two categories of genomic alterations: shared alterations, associated with tumorigenesis, and dedifferentiated-specific alterations, associated with malignant transformation. This large-scale genomic analysis reveals the mechanisms underlying the development and progression of DDLPS and provides insights that could contribute to the refinement of DDLPS management.

Suggested Citation

  • Makoto Hirata & Naofumi Asano & Kotoe Katayama & Akihiko Yoshida & Yusuke Tsuda & Masaya Sekimizu & Sachiyo Mitani & Eisuke Kobayashi & Motokiyo Komiyama & Hiroyuki Fujimoto & Takahiro Goto & Yukihide, 2019. "Integrated exome and RNA sequencing of dedifferentiated liposarcoma," Nature Communications, Nature, vol. 10(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-13286-z
    DOI: 10.1038/s41467-019-13286-z
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    Cited by:

    1. Shaoshuai Tang & Yunzhi Wang & Rongkui Luo & Rundong Fang & Yufeng Liu & Hang Xiang & Peng Ran & Yexin Tong & Mingjun Sun & Subei Tan & Wen Huang & Jie Huang & Jiacheng Lv & Ning Xu & Zhenmei Yao & Qi, 2024. "Proteomic characterization identifies clinically relevant subgroups of soft tissue sarcoma," Nature Communications, Nature, vol. 15(1), pages 1-24, December.
    2. Benjamin A. Nacev & Francisco Sanchez-Vega & Shaleigh A. Smith & Cristina R. Antonescu & Evan Rosenbaum & Hongyu Shi & Cerise Tang & Nicholas D. Socci & Satshil Rana & Rodrigo Gularte-Mérida & Ahmet Z, 2022. "Clinical sequencing of soft tissue and bone sarcomas delineates diverse genomic landscapes and potential therapeutic targets," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    3. Nadège Gruel & Chloé Quignot & Laëtitia Lesage & Sophie El Zein & Sylvie Bonvalot & Dimitri Tzanis & Khadija Ait Rais & Fabien Quinquis & Bastien Manciot & Julien Vibert & Nadine El Tannir & Ahmed Dah, 2024. "Cellular origin and clonal evolution of human dedifferentiated liposarcoma," Nature Communications, Nature, vol. 15(1), pages 1-18, December.

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