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Prefrontal cortical ChAT-VIP interneurons provide local excitation by cholinergic synaptic transmission and control attention

Author

Listed:
  • Joshua Obermayer

    (Vrije Universiteit)

  • Antonio Luchicchi

    (Vrije Universiteit
    Vrije Universiteit)

  • Tim S. Heistek

    (Vrije Universiteit)

  • Sybren F. Kloet

    (Vrije Universiteit)

  • Huub Terra

    (Vrije Universiteit)

  • Bastiaan Bruinsma

    (Vrije Universiteit)

  • Ouissame Mnie-Filali

    (Vrije Universiteit)

  • Christian Kortleven

    (Vrije Universiteit)

  • Anna A. Galakhova

    (Vrije Universiteit)

  • Ayoub J. Khalil

    (Vrije Universiteit)

  • Tim Kroon

    (Vrije Universiteit
    MRC Centre-Developmental Neurobiology, King’s College London)

  • Allert J. Jonker

    (Vrije Universiteit)

  • Roel Haan

    (Vrije Universiteit)

  • Wilma D. J. Berg

    (Vrije Universiteit)

  • Natalia A. Goriounova

    (Vrije Universiteit)

  • Christiaan P. J. Kock

    (Vrije Universiteit)

  • Tommy Pattij

    (Vrije Universiteit)

  • Huibert D. Mansvelder

    (Vrije Universiteit)

Abstract

Neocortical choline acetyltransferase (ChAT)-expressing interneurons are a subclass of vasoactive intestinal peptide (ChAT-VIP) neurons of which circuit and behavioural function are unknown. Here, we show that ChAT-VIP neurons directly excite neighbouring neurons in several layers through fast synaptic transmission of acetylcholine (ACh) in rodent medial prefrontal cortex (mPFC). Both interneurons in layers (L)1–3 as well as pyramidal neurons in L2/3 and L6 receive direct inputs from ChAT-VIP neurons mediated by fast cholinergic transmission. A fraction (10–20%) of postsynaptic neurons that received cholinergic input from ChAT-VIP interneurons also received GABAergic input from these neurons. In contrast to regular VIP interneurons, ChAT-VIP neurons did not disinhibit pyramidal neurons. Finally, we show that activity of these neurons is relevant for behaviour and they control attention behaviour distinctly from basal forebrain ACh inputs. Thus, ChAT-VIP neurons are a local source of cortical ACh that directly excite neurons throughout cortical layers and contribute to attention.

Suggested Citation

  • Joshua Obermayer & Antonio Luchicchi & Tim S. Heistek & Sybren F. Kloet & Huub Terra & Bastiaan Bruinsma & Ouissame Mnie-Filali & Christian Kortleven & Anna A. Galakhova & Ayoub J. Khalil & Tim Kroon , 2019. "Prefrontal cortical ChAT-VIP interneurons provide local excitation by cholinergic synaptic transmission and control attention," Nature Communications, Nature, vol. 10(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-13244-9
    DOI: 10.1038/s41467-019-13244-9
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    Cited by:

    1. Qingtao Sun & Jianping Zhang & Anan Li & Mei Yao & Guangcai Liu & Siqi Chen & Yue Luo & Zhi Wang & Hui Gong & Xiangning Li & Qingming Luo, 2022. "Acetylcholine deficiency disrupts extratelencephalic projection neurons in the prefrontal cortex in a mouse model of Alzheimer’s disease," Nature Communications, Nature, vol. 13(1), pages 1-22, December.

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