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Stroke among cancer patients

Author

Listed:
  • Nicholas G. Zaorsky

    (Penn State Cancer Institute
    Penn State College of Medicine)

  • Ying Zhang

    (Penn State College of Medicine)

  • Leila T. Tchelebi

    (Penn State Cancer Institute)

  • Heath B. Mackley

    (Penn State Cancer Institute)

  • Vernon M. Chinchilli

    (Penn State College of Medicine)

  • Brad E. Zacharia

    (Penn State College of Medicine)

Abstract

We identify cancer patients at highest risk of fatal stroke. This is a population-based study using nationally representative data from the Surveillance, Epidemiology, and End Results program, 1992-2015. Among 7,529,481 cancer patients, 80,513 died of fatal stroke (with 262,461 person-years at risk); the rate of fatal stroke was 21.64 per 100,000-person years, and the standardized mortality ratio (SMR) of fatal stroke was 2.17 (95% CI, 2.15, 2.19). Patients with cancer of the prostate, breast, and colorectum contribute to the plurality of cancer patients dying of fatal stroke. Brain and gastrointestinal cancer patients had the highest SMRs (>2-5) through the follow up period. Among those diagnosed at 40, from cancers of the prostate, breast, and colorectum. For almost all cancers survivors, the risk of stroke increases with time.

Suggested Citation

  • Nicholas G. Zaorsky & Ying Zhang & Leila T. Tchelebi & Heath B. Mackley & Vernon M. Chinchilli & Brad E. Zacharia, 2019. "Stroke among cancer patients," Nature Communications, Nature, vol. 10(1), pages 1-8, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-13120-6
    DOI: 10.1038/s41467-019-13120-6
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    Cited by:

    1. Kyle Mani & Daxuan Deng & Christine Lin & Ming Wang & Melinda L. Hsu & Nicholas G. Zaorsky, 2024. "Causes of death among people living with metastatic cancer," Nature Communications, Nature, vol. 15(1), pages 1-9, December.
    2. Xufei Bian & Ling Yang & Dingxi Jiang & Adam J. Grippin & Yifan Ma & Shuang Wu & Linchong Wu & Xiaoyou Wang & Zhongjie Tang & Kaicheng Tang & Weidong Pan & Shiyan Dong & Betty Y. S. Kim & Wen Jiang & , 2024. "Regulation of cerebral blood flow boosts precise brain targeting of vinpocetine-derived ionizable-lipidoid nanoparticles," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    3. Xiaocang Xu & Haoran Yang, 2022. "Elderly chronic diseases and catastrophic health expenditure: an important cause of Borderline Poor Families’ return to poverty in rural China," Palgrave Communications, Palgrave Macmillan, vol. 9(1), pages 1-10, December.

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