IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v10y2019i1d10.1038_s41467-019-13118-0.html
   My bibliography  Save this article

Characterization of antibiotic resistance genes in the species of the rumen microbiota

Author

Listed:
  • Yasmin Neves Vieira Sabino

    (Universidade Federal de Viçosa)

  • Mateus Ferreira Santana

    (Universidade Federal de Viçosa)

  • Linda Boniface Oyama

    (Queen’s University Belfast)

  • Fernanda Godoy Santos

    (Queen’s University Belfast)

  • Ana Júlia Silva Moreira

    (Universidade Federal de Viçosa)

  • Sharon Ann Huws

    (Queen’s University Belfast)

  • Hilário Cuquetto Mantovani

    (Universidade Federal de Viçosa)

Abstract

Infections caused by multidrug resistant bacteria represent a therapeutic challenge both in clinical settings and in livestock production, but the prevalence of antibiotic resistance genes among the species of bacteria that colonize the gastrointestinal tract of ruminants is not well characterized. Here, we investigate the resistome of 435 ruminal microbial genomes in silico and confirm representative phenotypes in vitro. We find a high abundance of genes encoding tetracycline resistance and evidence that the tet(W) gene is under positive selective pressure. Our findings reveal that tet(W) is located in a novel integrative and conjugative element in several ruminal bacterial genomes. Analyses of rumen microbial metatranscriptomes confirm the expression of the most abundant antibiotic resistance genes. Our data provide insight into antibiotic resistange gene profiles of the main species of ruminal bacteria and reveal the potential role of mobile genetic elements in shaping the resistome of the rumen microbiome, with implications for human and animal health.

Suggested Citation

  • Yasmin Neves Vieira Sabino & Mateus Ferreira Santana & Linda Boniface Oyama & Fernanda Godoy Santos & Ana Júlia Silva Moreira & Sharon Ann Huws & Hilário Cuquetto Mantovani, 2019. "Characterization of antibiotic resistance genes in the species of the rumen microbiota," Nature Communications, Nature, vol. 10(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-13118-0
    DOI: 10.1038/s41467-019-13118-0
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-019-13118-0
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-019-13118-0?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-13118-0. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.