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Optical molecular imaging can differentiate metastatic from benign lymph nodes in head and neck cancer

Author

Listed:
  • Naoki Nishio

    (Stanford University School of Medicine
    Nagoya University Graduate School of Medicine)

  • Nynke S. van den Berg

    (Stanford University School of Medicine)

  • Stan van Keulen

    (Stanford University School of Medicine
    VU University Medical Center/Academic Centre for Dentistry Amsterdam (ACTA))

  • Brock A. Martin

    (Stanford University School of Medicine)

  • Shayan Fakurnejad

    (Stanford University School of Medicine)

  • Nutte Teraphongphom

    (Stanford University School of Medicine)

  • Stefania U. Chirita

    (Stanford University School of Medicine)

  • Nicholas J. Oberhelman

    (Stanford University School of Medicine)

  • Guolan Lu

    (Stanford University School of Medicine)

  • Crista E. Horton

    (Stanford University School of Medicine)

  • Michael J. Kaplan

    (Stanford University School of Medicine)

  • Vasu Divi

    (Stanford University School of Medicine)

  • A. Dimitrios Colevas

    (Stanford University School of Medicine)

  • Eben L. Rosenthal

    (Stanford University School of Medicine)

Abstract

Identification of lymph node (LN) metastasis is essential for staging of solid tumors, and as a result, surgeons focus on harvesting significant numbers of LNs during ablative procedures for pathological evaluation. Isolating those LNs most likely to harbor metastatic disease can allow for a more rigorous evaluation of fewer LNs. Here we evaluate the impact of a systemically injected, near-infrared fluorescently-labeled, tumor-targeting contrast agent, panitumumab-IRDye800CW, to facilitate the identification of metastatic LNs in the ex vivo setting for head and neck cancer patients. Molecular imaging demonstrates a significantly higher mean fluorescence signal in metastatic LNs compared to benign LNs in head and neck cancer patients undergoing an elective neck dissection. Molecular imaging to preselect at-risk LNs may thus allow a more rigorous examination of LNs and subsequently lead to improved prognostication than regular neck dissection.

Suggested Citation

  • Naoki Nishio & Nynke S. van den Berg & Stan van Keulen & Brock A. Martin & Shayan Fakurnejad & Nutte Teraphongphom & Stefania U. Chirita & Nicholas J. Oberhelman & Guolan Lu & Crista E. Horton & Micha, 2019. "Optical molecular imaging can differentiate metastatic from benign lymph nodes in head and neck cancer," Nature Communications, Nature, vol. 10(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-13076-7
    DOI: 10.1038/s41467-019-13076-7
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    Cited by:

    1. Xianghan Zhang & Jingkai Gao & Yingdi Tang & Jie Yu & Si Si Liew & Chaoqiang Qiao & Yutian Cao & Guohuan Liu & Hongyu Fan & Yuqiong Xia & Jie Tian & Kanyi Pu & Zhongliang Wang, 2022. "Bioorthogonally activatable cyanine dye with torsion-induced disaggregation for in vivo tumor imaging," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    2. Gregory T. Kennedy & Feredun S. Azari & Elizabeth Bernstein & Bilal Nadeem & Ashley Chang & Alix Segil & Sean Carlin & Neil T. Sullivan & Emmanuel Encarnado & Charuhas Desphande & Sumith Kularatne & P, 2022. "Targeted detection of cancer at the cellular level during biopsy by near-infrared confocal laser endomicroscopy," Nature Communications, Nature, vol. 13(1), pages 1-9, December.

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