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Impact of delivery mode-associated gut microbiota dynamics on health in the first year of life

Author

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  • Marta Reyman

    (Wilhelmina Children’s Hospital of University Medical Centre
    Spaarne Gasthuis Academy Hoofddorp and Haarlem)

  • Marlies A. Houten

    (Spaarne Gasthuis Academy Hoofddorp and Haarlem)

  • Debbie Baarle

    (National Institute for Public Health and the Environment)

  • Astrid A. T. M. Bosch

    (Wilhelmina Children’s Hospital of University Medical Centre)

  • Wing Ho Man

    (Wilhelmina Children’s Hospital of University Medical Centre
    Spaarne Gasthuis Academy Hoofddorp and Haarlem)

  • Mei Ling J. N. Chu

    (Wilhelmina Children’s Hospital of University Medical Centre)

  • Kayleigh Arp

    (Wilhelmina Children’s Hospital of University Medical Centre)

  • Rebecca L. Watson

    (Medical Research Council/University of Edinburgh Centre for Inflammation Research, Queen’s Medical Research Institute, University of Edinburgh)

  • Elisabeth A. M. Sanders

    (Wilhelmina Children’s Hospital of University Medical Centre
    National Institute for Public Health and the Environment)

  • Susana Fuentes

    (National Institute for Public Health and the Environment)

  • Debby Bogaert

    (Wilhelmina Children’s Hospital of University Medical Centre
    Medical Research Council/University of Edinburgh Centre for Inflammation Research, Queen’s Medical Research Institute, University of Edinburgh)

Abstract

The early-life microbiome appears to be affected by mode of delivery, but this effect may depend on intrapartum antibiotic exposure. Here, we assess the effect of delivery mode on gut microbiota, independent of intrapartum antibiotics, by postponing routine antibiotic administration to mothers until after cord clamping in 74 vaginally delivered and 46 caesarean section born infants. The microbiota differs between caesarean section born and vaginally delivered infants over the first year of life, showing enrichment of Bifidobacterium spp., and reduction of Enterococcus and Klebsiella spp. in vaginally delivered infants. The microbiota composition at one week of life is associated with the number of respiratory infections over the first year. The taxa driving this association are more abundant in caesarean section born children, providing a possible link between mode of delivery and susceptibility to infectious outcomes.

Suggested Citation

  • Marta Reyman & Marlies A. Houten & Debbie Baarle & Astrid A. T. M. Bosch & Wing Ho Man & Mei Ling J. N. Chu & Kayleigh Arp & Rebecca L. Watson & Elisabeth A. M. Sanders & Susana Fuentes & Debby Bogaer, 2019. "Impact of delivery mode-associated gut microbiota dynamics on health in the first year of life," Nature Communications, Nature, vol. 10(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-13014-7
    DOI: 10.1038/s41467-019-13014-7
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