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Altered structural brain asymmetry in autism spectrum disorder in a study of 54 datasets

Author

Listed:
  • Merel C. Postema

    (Max Planck Institute for Psycholinguistics)

  • Daan Rooij

    (Radboud University Medical Centre)

  • Evdokia Anagnostou

    (University of Toronto)

  • Celso Arango

    (Universidad Complutense, IiSGM, CIBERSAM)

  • Guillaume Auzias

    (Institut de Neurosciences de la Timone, UMR 7289, Aix Marseille Université, CNRS)

  • Marlene Behrmann

    (Carnegie Mellon University)

  • Geraldo Busatto Filho

    (Universidade de Sao Paulo)

  • Sara Calderoni

    (IRCCS Stella Maris Foundation, viale del Tirreno 331
    University of Pisa)

  • Rosa Calvo

    (2017SGR881, University of Barcelona, IDIBAPS, CIBERSAM)

  • Eileen Daly

    (Psychology & Neuroscience King’s College London)

  • Christine Deruelle

    (Institut de Neurosciences de la Timone, UMR 7289, Aix Marseille Université, CNRS)

  • Adriana Martino

    (NYU Child Study Center)

  • Ilan Dinstein

    (Ben-Gurion University of the Negev)

  • Fabio Luis S. Duran

    (Universidade de Sao Paulo)

  • Sarah Durston

    (University Medical Center Utrecht)

  • Christine Ecker

    (Goethe University Frankfurt am Main
    University of Southern California)

  • Stefan Ehrlich

    (TU Dresden)

  • Damien Fair

    (Oregon Health & Science University)

  • Jennifer Fedor

    (University of Pittsburgh)

  • Xin Feng

    (Jilin University, Changchun)

  • Jackie Fitzgerald

    (Trinity College
    Trinity College)

  • Dorothea L. Floris

    (Radboud University Medical Centre)

  • Christine M. Freitag

    (Goethe University Frankfurt am Main)

  • Louise Gallagher

    (Trinity College
    Trinity College)

  • David C. Glahn

    (Boston Children’s Hospital and Harvard Medical School
    Olin Neuropsychiatric Research Center)

  • Ilaria Gori

    (Pisa Division, Largo B. Pontecorvo 3)

  • Shlomi Haar

    (Imperial College London)

  • Liesbeth Hoekstra

    (Radboud University Medical Centre
    Karakter Child and Adolescent Psychiatry University Centre)

  • Neda Jahanshad

    (University of Southern California)

  • Maria Jalbrzikowski

    (Trinity College)

  • Joost Janssen

    (Universidad Complutense, IiSGM, CIBERSAM)

  • Joseph A. King

    (TU Dresden)

  • Xiang Zhen Kong

    (Max Planck Institute for Psycholinguistics)

  • Luisa Lazaro

    (2017SGR881, University of Barcelona, IDIBAPS, CIBERSAM)

  • Jason P. Lerch

    (The Hospital for Sick Children
    University of Toronto)

  • Beatriz Luna

    (University of Pittsburgh)

  • Mauricio M. Martinho

    (Universidade Federal de Santa Maria)

  • Jane McGrath

    (Trinity College
    Trinity College)

  • Sarah E. Medland

    (QIMR Berghofer Medical Research Institute)

  • Filippo Muratori

    (IRCCS Stella Maris Foundation, viale del Tirreno 331
    University of Pisa)

  • Clodagh M. Murphy

    (Psychology & Neuroscience King’s College London
    South London and Maudsley Foundation NHS Trust)

  • Declan G. M. Murphy

    (South London and Maudsley Foundation NHS Trust
    King’s College London)

  • Kirsten O’Hearn

    (University of Pittsburgh)

  • Bob Oranje

    (University Medical Center Utrecht)

  • Mara Parellada

    (Universidad Complutense, IiSGM, CIBERSAM)

  • Olga Puig

    (2017SGR881, University of Barcelona, IDIBAPS, CIBERSAM)

  • Alessandra Retico

    (Pisa Division, Largo B. Pontecorvo 3)

  • Pedro Rosa

    (Universidade de Sao Paulo)

  • Katya Rubia

    (Kings College London)

  • Devon Shook

    (University Medical Center Utrecht)

  • Margot J. Taylor

    (University of Toronto)

  • Michela Tosetti

    (IRCCS Stella Maris Foundation, viale del Tirreno 331)

  • Gregory L. Wallace

    (The George Washington University)

  • Fengfeng Zhou

    (Jilin University, Changchun)

  • Paul M. Thompson

    (University of Southern California)

  • Simon E. Fisher

    (Max Planck Institute for Psycholinguistics
    Radboud University)

  • Jan K. Buitelaar

    (Radboud University Medical Centre)

  • Clyde Francks

    (Max Planck Institute for Psycholinguistics
    Radboud University)

Abstract

Altered structural brain asymmetry in autism spectrum disorder (ASD) has been reported. However, findings have been inconsistent, likely due to limited sample sizes. Here we investigated 1,774 individuals with ASD and 1,809 controls, from 54 independent data sets of the ENIGMA consortium. ASD was significantly associated with alterations of cortical thickness asymmetry in mostly medial frontal, orbitofrontal, cingulate and inferior temporal areas, and also with asymmetry of orbitofrontal surface area. These differences generally involved reduced asymmetry in individuals with ASD compared to controls. Furthermore, putamen volume asymmetry was significantly increased in ASD. The largest case-control effect size was Cohen’s d = −0.13, for asymmetry of superior frontal cortical thickness. Most effects did not depend on age, sex, IQ, severity or medication use. Altered lateralized neurodevelopment may therefore be a feature of ASD, affecting widespread brain regions with diverse functions. Large-scale analysis was necessary to quantify subtle alterations of brain structural asymmetry in ASD.

Suggested Citation

  • Merel C. Postema & Daan Rooij & Evdokia Anagnostou & Celso Arango & Guillaume Auzias & Marlene Behrmann & Geraldo Busatto Filho & Sara Calderoni & Rosa Calvo & Eileen Daly & Christine Deruelle & Adria, 2019. "Altered structural brain asymmetry in autism spectrum disorder in a study of 54 datasets," Nature Communications, Nature, vol. 10(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-13005-8
    DOI: 10.1038/s41467-019-13005-8
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    Cited by:

    1. Dick Schijven & Sourena Soheili-Nezhad & Simon E. Fisher & Clyde Francks, 2024. "Exome-wide analysis implicates rare protein-altering variants in human handedness," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    2. Zhiqiang Sha & Dick Schijven & Amaia Carrion-Castillo & Marc Joliot & Bernard Mazoyer & Simon E. Fisher & Fabrice Crivello & Clyde Francks, 2021. "The genetic architecture of structural left–right asymmetry of the human brain," Nature Human Behaviour, Nature, vol. 5(9), pages 1226-1239, September.

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