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ESCRT-III-driven piecemeal micro-ER-phagy remodels the ER during recovery from ER stress

Author

Listed:
  • Marisa Loi

    (Università della Svizzera italiana (USI)
    Swiss Federal Institute of Technology)

  • Andrea Raimondi

    (San Raffaele Scientific Institute)

  • Diego Morone

    (Università della Svizzera italiana (USI))

  • Maurizio Molinari

    (Università della Svizzera italiana (USI)
    École Polytechnique Fédérale de Lausanne)

Abstract

The endoplasmic reticulum (ER) produces about 40% of the nucleated cell’s proteome. ER size and content in molecular chaperones increase upon physiologic and pathologic stresses on activation of unfolded protein responses (UPR). On stress resolution, the mammalian ER is remodeled to pre-stress, physiologic size and function on activation of the LC3-binding activity of the translocon component SEC62. This elicits recov-ER-phagy, i.e., the delivery of the excess ER generated during the phase of stress to endolysosomes (EL) for clearance. Here, ultrastructural and genetic analyses reveal that recov-ER-phagy entails the LC3 lipidation machinery and proceeds via piecemeal micro-ER-phagy, where RAB7/LAMP1-positive EL directly engulf excess ER in processes that rely on the Endosomal Sorting Complex Required for Transport (ESCRT)-III component CHMP4B and the accessory AAA+ ATPase VPS4A. Thus, ESCRT-III-driven micro-ER-phagy emerges as a key catabolic pathway activated to remodel the mammalian ER on recovery from ER stress.

Suggested Citation

  • Marisa Loi & Andrea Raimondi & Diego Morone & Maurizio Molinari, 2019. "ESCRT-III-driven piecemeal micro-ER-phagy remodels the ER during recovery from ER stress," Nature Communications, Nature, vol. 10(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-12991-z
    DOI: 10.1038/s41467-019-12991-z
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    Cited by:

    1. Yun Lan & Sophie Wilhelmina Leur & Julia Ayano Fernando & Ho Him Wong & Martin Kampmann & Lewis Siu & Jingshu Zhang & Mingyuan Li & John M. Nicholls & Sumana Sanyal, 2023. "Viral subversion of selective autophagy is critical for biogenesis of virus replication organelles," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    2. Marika K. Kucińska & Juliette Fedry & Carmela Galli & Diego Morone & Andrea Raimondi & Tatiana Soldà & Friedrich Förster & Maurizio Molinari, 2023. "TMX4-driven LINC complex disassembly and asymmetric autophagy of the nuclear envelope upon acute ER stress," Nature Communications, Nature, vol. 14(1), pages 1-20, December.

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