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Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration

Author

Listed:
  • Raymond Noordam

    (Leiden University Medical Center)

  • Maxime M. Bos

    (Leiden University Medical Center)

  • Heming Wang

    (Brigham and Women’s Hospital)

  • Thomas W. Winkler

    (University of Regensburg)

  • Amy R. Bentley

    (National Institutes of Health)

  • Tuomas O. Kilpeläinen

    (University of Copenhagen
    The Icahn School of Medicine at Mount Sinai, New York)

  • Paul S. Vries

    (The University of Texas Health Science Center at Houston)

  • Yun Ju Sung

    (Washington University School of Medicine)

  • Karen Schwander

    (Washington University School of Medicine)

  • Brian E. Cade

    (Brigham and Women’s Hospital)

  • Alisa Manning

    (Massachusetts General Hospital
    Harvard Medical School)

  • Hugues Aschard

    (Harvard School of Public Health
    Biostatistique et Biologie Intégrative (C3BI), Institut Pasteur)

  • Michael R. Brown

    (The University of Texas Health Science Center at Houston)

  • Han Chen

    (The University of Texas Health Science Center at Houston
    The University of Texas Health Science Center at Houston)

  • Nora Franceschini

    (University of North Carolina)

  • Solomon K. Musani

    (University of Mississippi Medical Center)

  • Melissa Richard

    (The University of Texas Health Science Center at Houston)

  • Dina Vojinovic

    (Erasmus University Medical Center)

  • Stella Aslibekyan

    (University of Alabama at Birmingham)

  • Traci M. Bartz

    (University of Washington)

  • Lisa las Fuentes

    (Washington University School of Medicine
    Washington University School of Medicine)

  • Mary Feitosa

    (Washington University School of Medicine)

  • Andrea R. Horimoto

    (University of São Paulo Medical School)

  • Marjan Ilkov

    (Icelandic Heart Association)

  • Minjung Kho

    (University of Michigan)

  • Aldi Kraja

    (Washington University School of Medicine)

  • Changwei Li

    (University of Georgia at Athens College of Public Health)

  • Elise Lim

    (Boston University School of Public Health)

  • Yongmei Liu

    (Wake Forest University Health Sciences)

  • Dennis O. Mook-Kanamori

    (Leiden University Medical Center
    Leiden University Medical Center)

  • Tuomo Rankinen

    (Pennington Biomedical Research Center)

  • Salman M. Tajuddin

    (National Institutes of Health)

  • Ashley Spek

    (Erasmus University Medical Center)

  • Zhe Wang

    (The University of Texas Health Science Center at Houston)

  • Jonathan Marten

    (University of Edinburgh)

  • Vincent Laville

    (Biostatistique et Biologie Intégrative (C3BI), Institut Pasteur)

  • Maris Alver

    (University of Tartu
    University of Tartu)

  • Evangelos Evangelou

    (Imperial College London
    University of Ioannina Medical School)

  • Maria E. Graff

    (University of North Carolina)

  • Meian He

    (Huazhong University of Science and Technology)

  • Brigitte Kühnel

    (German Research Center for Environmental Health
    German Research Center for Environmental Health)

  • Leo-Pekka Lyytikäinen

    (Fimlab Laboratories
    Tampere University)

  • Pedro Marques-Vidal

    (Lausanne University Hospital)

  • Ilja M. Nolte

    (University of Groningen, University Medical Center Groningen, Department of Epidemiology)

  • Nicholette D. Palmer

    (Biochemistry, Wake Forest School of Medicine)

  • Rainer Rauramaa

    (Kuopio Research Institute of Exercise Medicine)

  • Xiao-Ou Shu

    (Vanderbilt University School of Medicine)

  • Harold Snieder

    (University of Groningen, University Medical Center Groningen, Department of Epidemiology)

  • Stefan Weiss

    (University Medicine Greifswald)

  • Wanqing Wen

    (Vanderbilt University School of Medicine)

  • Lisa R. Yanek

    (Johns Hopkins University School of Medicine)

  • Correa Adolfo

    (University of Mississippi Medical Center)

  • Christie Ballantyne

    (Baylor College of Medicine
    Houston Methodist Debakey Heart and Vascular Center)

  • Larry Bielak

    (University of Michigan)

  • Nienke R. Biermasz

    (Leiden University Medical Center
    Einthoven Laboratory for Experimental Vascular Medicine)

  • Eric Boerwinkle

    (The University of Texas Health Science Center at Houston
    Baylor College of Medicine)

  • Niki Dimou

    (University of Ioannina Medical School)

  • Gudny Eiriksdottir

    (Icelandic Heart Association)

  • Chuan Gao

    (Wake Forest School of Medicine)

  • Sina A. Gharib

    (University of Washington)

  • Daniel J. Gottlieb

    (Brigham and Women’s Hospital
    Harvard Medical School
    VA Boston Healthcare System)

  • José Haba-Rubio

    (Lausanne University Hospital)

  • Tamara B. Harris

    (National Institutes of Health)

  • Sami Heikkinen

    (University of Eastern Finland
    University of Eastern Finland)

  • Raphaël Heinzer

    (Lausanne University Hospital)

  • James E. Hixson

    (The University of Texas Health Science Center at Houston)

  • Georg Homuth

    (University Medicine Greifswald)

  • M. Arfan Ikram

    (Erasmus University Medical Center
    Erasmus University Medical Center)

  • Pirjo Komulainen

    (Kuopio Research Institute of Exercise Medicine)

  • Jose E. Krieger

    (University of São Paulo Medical School)

  • Jiwon Lee

    (Brigham and Women’s Hospital)

  • Jingmin Liu

    (University of Washington School of Public Health)

  • Kurt K. Lohman

    (Wake Forest University Health Sciences)

  • Annemarie I. Luik

    (Erasmus University Medical Center)

  • Reedik Mägi

    (University of Tartu)

  • Lisa W. Martin

    (George Washington University)

  • Thomas Meitinger

    (German Research Center for Environmental Health)

  • Andres Metspalu

    (University of Tartu
    University of Tartu)

  • Yuri Milaneschi

    (George Washington University)

  • Mike A. Nalls

    (National Institute on Aging
    Data Tecnica International)

  • Jeff O’Connell

    (University of Maryland School of Medicine
    University of Maryland School of Medicine)

  • Annette Peters

    (German Research Center for Environmental Health
    partner site Munich Heart Alliance)

  • Patricia Peyser

    (University of Michigan)

  • Olli T. Raitakari

    (Turku University Hospital
    University of Turku)

  • Alex P. Reiner

    (University of Washington School of Public Health)

  • Patrick C. N. Rensen

    (Leiden University Medical Center
    Einthoven Laboratory for Experimental Vascular Medicine)

  • Treva K. Rice

    (Washington University School of Medicine)

  • Stephen S. Rich

    (University of Virginia)

  • Till Roenneberg

    (Ludwig-Maximilians-Universitat Munchen)

  • Jerome I. Rotter

    (LABioMed at Harbor-UCLA Medical Center)

  • Pamela J. Schreiner

    (University of Minnesota)

  • James Shikany

    (University of Alabama at Birmingham)

  • Stephen S. Sidney

    (Division of Research, Kaiser Permanente Northern California)

  • Mario Sims

    (University of Mississippi Medical Center)

  • Colleen M. Sitlani

    (University of Washington)

  • Tamar Sofer

    (Brigham and Women’s Hospital
    Technische Universität München)

  • Konstantin Strauch

    (German Research Center for Environmental Health
    Ludwig-Maximilians-Universitat Munchen)

  • Morris A. Swertz

    (University of Groningen, University Medical Center Groningen, Department of Genetics)

  • Kent D. Taylor

    (LABioMed at Harbor-UCLA Medical Center)

  • André G. Uitterlinden

    (Erasmus University Medical Center
    Erasmus University Medical Center)

  • Cornelia M. Duijn

    (Erasmus University Medical Center
    University of Oxford)

  • Henry Völzke

    (University Medicine Greifswald)

  • Melanie Waldenberger

    (German Research Center for Environmental Health
    German Research Center for Environmental Health
    partner site Munich Heart Alliance)

  • Robert B. Wallance

    (University of Iowa College of Public Health)

  • Ko Willems Dijk

    (Leiden University Medical Center
    Einthoven Laboratory for Experimental Vascular Medicine
    Leiden University Medical Center)

  • Caizheng Yu

    (Huazhong University of Science and Technology)

  • Alan B. Zonderman

    (National Institute on Aging, National Institutes of Health)

  • Diane M. Becker

    (Johns Hopkins University School of Medicine)

  • Paul Elliott

    (University of Tartu
    School of Public Health, Imperial College London
    National Institute of Health Research Imperial College London Biomedical Research Centre
    UK-DRI Dementia Research Institute at Imperial College London)

  • Tõnu Esko

    (University of Tartu
    Broad Institute of the Massachusetts Institute of Technology and Harvard University)

  • Christian Gieger

    (German Research Center for Environmental Health
    German Center for Diabetes Research (DZD e.V.))

  • Hans J. Grabe

    (University Medicine Greifswald)

  • Timo A. Lakka

    (Kuopio Research Institute of Exercise Medicine
    University of Eastern Finland
    Kuopia University Hospital)

  • Terho Lehtimäki

    (Fimlab Laboratories
    Tampere University)

  • Kari E. North

    (University of North Carolina)

  • Brenda W. J. H. Penninx

    (Amsterdam UMC, Vrije Universiteit)

  • Peter Vollenweider

    (Lausanne University Hospital)

  • Lynne E. Wagenknecht

    (Wake Forest School of Medicine)

  • Tangchun Wu

    (Huazhong University of Science and Technology)

  • Yong-Bing Xiang

    (Shanghai Jiaotong University School of Medicine)

  • Wei Zheng

    (Vanderbilt University School of Medicine)

  • Donna K. Arnett

    (University of Kentucky College of Public Health)

  • Claude Bouchard

    (Pennington Biomedical Research Center)

  • Michele K. Evans

    (National Institutes of Health)

  • Vilmundur Gudnason

    (Icelandic Heart Association
    University of Iceland)

  • Sharon Kardia

    (University of Michigan)

  • Tanika N. Kelly

    (Epidemiology, Tulane University School of Public Health and Tropical Medicine)

  • Stephen B. Kritchevsky

    (Wake Forest School of Medicine)

  • Ruth J. F. Loos

    (The Icahn School of Medicine at Mount Sinai
    The Icahn School of Medicine at Mount Sinai)

  • Alexandre C. Pereira

    (University of São Paulo Medical School)

  • Mike Province

    (Washington University School of Medicine)

  • Bruce M. Psaty

    (University of Washington
    Health Research Institute)

  • Charles Rotimi

    (National Institutes of Health)

  • Xiaofeng Zhu

    (Case Western Reserve University)

  • Najaf Amin

    (Erasmus University Medical Center)

  • L. Adrienne Cupples

    (Boston University School of Public Health
    NHLBI Framingham Heart Study)

  • Myriam Fornage

    (The University of Texas Health Science Center at Houston)

  • Ervin F. Fox

    (University of Mississippi Medical Center)

  • Xiuqing Guo

    (LABioMed at Harbor-UCLA Medical Center)

  • W. James Gauderman

    (University of Southern California)

  • Kenneth Rice

    (University of Washington)

  • Charles Kooperberg

    (University of Washington School of Public Health)

  • Patricia B. Munroe

    (Queen Mary University of London
    Queen Mary University of London, London)

  • Ching-Ti Liu

    (Boston University School of Public Health)

  • Alanna C. Morrison

    (The University of Texas Health Science Center at Houston)

  • Dabeeru C. Rao

    (Washington University School of Medicine)

  • Diana Heemst

    (Leiden University Medical Center)

  • Susan Redline

    (Brigham and Women’s Hospital
    Division of Pulmonary Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School)

Abstract

Both short and long sleep are associated with an adverse lipid profile, likely through different biological pathways. To elucidate the biology of sleep-associated adverse lipid profile, we conduct multi-ancestry genome-wide sleep-SNP interaction analyses on three lipid traits (HDL-c, LDL-c and triglycerides). In the total study sample (discovery + replication) of 126,926 individuals from 5 different ancestry groups, when considering either long or short total sleep time interactions in joint analyses, we identify 49 previously unreported lipid loci, and 10 additional previously unreported lipid loci in a restricted sample of European-ancestry cohorts. In addition, we identify new gene-sleep interactions for known lipid loci such as LPL and PCSK9. The previously unreported lipid loci have a modest explained variance in lipid levels: most notable, gene-short-sleep interactions explain 4.25% of the variance in triglyceride level. Collectively, these findings contribute to our understanding of the biological mechanisms involved in sleep-associated adverse lipid profiles.

Suggested Citation

  • Raymond Noordam & Maxime M. Bos & Heming Wang & Thomas W. Winkler & Amy R. Bentley & Tuomas O. Kilpeläinen & Paul S. Vries & Yun Ju Sung & Karen Schwander & Brian E. Cade & Alisa Manning & Hugues Asch, 2019. "Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration," Nature Communications, Nature, vol. 10(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-12958-0
    DOI: 10.1038/s41467-019-12958-0
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