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Distinct CD1d docking strategies exhibited by diverse Type II NKT cell receptors

Author

Listed:
  • Catarina F. Almeida

    (University of Melbourne
    University of Melbourne)

  • Srinivasan Sundararaj

    (Monash University)

  • Jérôme Nours

    (Monash University
    Monash University)

  • T. Praveena

    (Monash University
    Monash University)

  • Benjamin Cao

    (University of Melbourne)

  • Satvika Burugupalli

    (University of Melbourne)

  • Dylan G. M. Smith

    (University of Melbourne)

  • Onisha Patel

    (Monash University)

  • Manfred Brigl

    (Harvard Medical School)

  • Daniel G. Pellicci

    (University of Melbourne
    University of Melbourne)

  • Spencer J. Williams

    (University of Melbourne
    University of Melbourne)

  • Adam P. Uldrich

    (University of Melbourne
    University of Melbourne)

  • Dale I. Godfrey

    (University of Melbourne
    University of Melbourne)

  • Jamie Rossjohn

    (Monash University
    Monash University
    Cardiff University School of Medicine)

Abstract

Type I and type II natural killer T (NKT) cells are restricted to the lipid antigen-presenting molecule CD1d. While we have an understanding of the antigen reactivity and function of type I NKT cells, our knowledge of type II NKT cells in health and disease remains unclear. Here we describe a population of type II NKT cells that recognise and respond to the microbial antigen, α-glucuronosyl-diacylglycerol (α-GlcADAG) presented by CD1d, but not the prototypical type I NKT cell agonist, α-galactosylceramide. Surprisingly, the crystal structure of a type II NKT TCR-CD1d-α-GlcADAG complex reveals a CD1d F’-pocket-docking mode that contrasts sharply with the previously determined A’-roof positioning of a sulfatide-reactive type II NKT TCR. Our data also suggest that diverse type II NKT TCRs directed against distinct microbial or mammalian lipid antigens adopt multiple recognition strategies on CD1d, thereby maximising the potential for type II NKT cells to detect different lipid antigens.

Suggested Citation

  • Catarina F. Almeida & Srinivasan Sundararaj & Jérôme Nours & T. Praveena & Benjamin Cao & Satvika Burugupalli & Dylan G. M. Smith & Onisha Patel & Manfred Brigl & Daniel G. Pellicci & Spencer J. Willi, 2019. "Distinct CD1d docking strategies exhibited by diverse Type II NKT cell receptors," Nature Communications, Nature, vol. 10(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-12941-9
    DOI: 10.1038/s41467-019-12941-9
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    Cited by:

    1. Catarina F. Almeida & Benjamin S. Gully & Claerwen M. Jones & Lukasz Kedzierski & Sachith D. Gunasinghe & Michael T. Rice & Richard Berry & Nicholas A. Gherardin & Trang T. Nguyen & Yee-Foong Mok & Jo, 2024. "Direct recognition of an intact foreign protein by an αβ T cell receptor," Nature Communications, Nature, vol. 15(1), pages 1-18, December.

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