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Intestinal microbiome composition and its relation to joint pain and inflammation

Author

Listed:
  • Cindy G. Boer

    (Erasmus MC, University Medical Center)

  • Djawad Radjabzadeh

    (Erasmus MC, University Medical Center)

  • Carolina Medina-Gomez

    (Erasmus MC, University Medical Center)

  • Sanzhima Garmaeva

    (University of Groningen)

  • Dieuwke Schiphof

    (University Medical Center)

  • Pascal Arp

    (Erasmus MC, University Medical Center)

  • Thomas Koet

    (Erasmus MC, University Medical Center)

  • Alexander Kurilshikov

    (University of Groningen)

  • Jingyuan Fu

    (University of Groningen
    University Medical Center Groningen, University of Groningen)

  • M. Arfan Ikram

    (University Medical Center Rotterdam)

  • Sita Bierma-Zeinstra

    (University Medical Center
    University Medical Center Rotterdam)

  • André G. Uitterlinden

    (Erasmus MC, University Medical Center
    University Medical Center Rotterdam)

  • Robert Kraaij

    (Erasmus MC, University Medical Center)

  • Alexandra Zhernakova

    (University of Groningen)

  • Joyce B. J. van Meurs

    (Erasmus MC, University Medical Center)

Abstract

Macrophage-mediated inflammation is thought to have a causal role in osteoarthritis-related pain and severity, and has been suggested to be triggered by endotoxins produced by the gastrointestinal microbiome. Here we investigate the relationship between joint pain and the gastrointestinal microbiome composition, and osteoarthritis-related knee pain in the Rotterdam Study; a large population based cohort study. We show that abundance of Streptococcus species is associated with increased knee pain, which we validate by absolute quantification of Streptococcus species. In addition, we replicate these results in 867 Caucasian adults of the Lifelines-DEEP study. Finally we show evidence that this association is driven by local inflammation in the knee joint. Our results indicate the microbiome is a possible therapeutic target for osteoarthritis-related knee pain.

Suggested Citation

  • Cindy G. Boer & Djawad Radjabzadeh & Carolina Medina-Gomez & Sanzhima Garmaeva & Dieuwke Schiphof & Pascal Arp & Thomas Koet & Alexander Kurilshikov & Jingyuan Fu & M. Arfan Ikram & Sita Bierma-Zeinst, 2019. "Intestinal microbiome composition and its relation to joint pain and inflammation," Nature Communications, Nature, vol. 10(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-12873-4
    DOI: 10.1038/s41467-019-12873-4
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    Cited by:

    1. Courtney M. Thomas & Elie Desmond-Le Quéméner & Simonetta Gribaldo & Guillaume Borrel, 2022. "Factors shaping the abundance and diversity of the gut archaeome across the animal kingdom," Nature Communications, Nature, vol. 13(1), pages 1-16, December.

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