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Mapping optogenetically-driven single-vessel fMRI with concurrent neuronal calcium recordings in the rat hippocampus

Author

Listed:
  • Xuming Chen

    (Max Planck Institute for Biological Cybernetics
    University of Tuebingen
    Wuhan University, Renmin Hospital)

  • Filip Sobczak

    (Max Planck Institute for Biological Cybernetics
    University of Tuebingen)

  • Yi Chen

    (Max Planck Institute for Biological Cybernetics
    University of Tuebingen)

  • Yuanyuan Jiang

    (Max Planck Institute for Biological Cybernetics
    Massachusetts General Hospital and Harvard Medical School)

  • Chunqi Qian

    (Michigan State University)

  • Zuneng Lu

    (Wuhan University, Renmin Hospital)

  • Cenk Ayata

    (Massachusetts General Hospital, Harvard Medical School
    Massachusetts General Hospital, Harvard Medical School)

  • Nikos K. Logothetis

    (Max Planck Institute for Biological Cybernetics
    University of Manchester)

  • Xin Yu

    (Max Planck Institute for Biological Cybernetics
    Massachusetts General Hospital and Harvard Medical School)

Abstract

Extensive in vivo imaging studies investigate the hippocampal neural network function, mainly focusing on the dorsal CA1 region given its optical accessibility. Multi-modality fMRI with simultaneous hippocampal electrophysiological recording reveal broad cortical correlation patterns, but the detailed spatial hippocampal functional map remains lacking given the limited fMRI resolution. In particular, hemodynamic responses linked to specific neural activity are unclear at the single-vessel level across hippocampal vasculature, which hinders the deciphering of the hippocampal malfunction in animal models and the translation to critical neurovascular coupling (NVC) patterns for human fMRI. We simultaneously acquired optogenetically-driven neuronal Ca2+ signals with single-vessel blood-oxygen-level-dependent (BOLD) and cerebral-blood-volume (CBV)-fMRI from individual venules and arterioles. Distinct spatiotemporal patterns of hippocampal hemodynamic responses were correlated to optogenetically evoked and spreading depression-like calcium events. The calcium event-related single-vessel hemodynamic modeling revealed significantly reduced NVC efficiency upon spreading depression-like (SDL) events, providing a direct measure of the NVC function at various hippocampal states.

Suggested Citation

  • Xuming Chen & Filip Sobczak & Yi Chen & Yuanyuan Jiang & Chunqi Qian & Zuneng Lu & Cenk Ayata & Nikos K. Logothetis & Xin Yu, 2019. "Mapping optogenetically-driven single-vessel fMRI with concurrent neuronal calcium recordings in the rat hippocampus," Nature Communications, Nature, vol. 10(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-12850-x
    DOI: 10.1038/s41467-019-12850-x
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    Cited by:

    1. Domenic H. Cerri & Daniel L. Albaugh & Lindsay R. Walton & Brittany Katz & Tzu-Wen Wang & Tzu-Hao Harry Chao & Weiting Zhang & Randal J. Nonneman & Jing Jiang & Sung-Ho Lee & Amit Etkin & Catherine N., 2024. "Distinct neurochemical influences on fMRI response polarity in the striatum," Nature Communications, Nature, vol. 15(1), pages 1-23, December.

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