IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v10y2019i1d10.1038_s41467-019-12842-x.html
   My bibliography  Save this article

Bacterial MgrB peptide activates chemoreceptor Fpr3 in mouse accessory olfactory system and drives avoidance behaviour

Author

Listed:
  • Bernd Bufe

    (Saarland University
    University of Applied Sciences Kaiserslautern)

  • Yannick Teuchert

    (Saarland University)

  • Andreas Schmid

    (Saarland University)

  • Martina Pyrski

    (Saarland University)

  • Anabel Pérez-Gómez

    (Saarland University
    The Scripps Research Institute)

  • Janina Eisenbeis

    (Saarland University)

  • Thomas Timm

    (Justus-Liebig-University Giessen)

  • Tomohiro Ishii

    (Max Planck Research Unit for Neurogenetics
    Tokyo Medical and Dental University)

  • Günter Lochnit

    (Justus-Liebig-University Giessen)

  • Markus Bischoff

    (Saarland University)

  • Peter Mombaerts

    (Max Planck Research Unit for Neurogenetics)

  • Trese Leinders-Zufall

    (Saarland University)

  • Frank Zufall

    (Saarland University)

Abstract

Innate immune chemoreceptors of the formyl peptide receptor (Fpr) family are expressed by vomeronasal sensory neurons (VSNs) in the accessory olfactory system. Their biological function and coding mechanisms remain unknown. We show that mouse Fpr3 (Fpr-rs1) recognizes the core peptide motif f-MKKFRW that is predominantly present in the signal sequence of the bacterial protein MgrB, a highly conserved regulator of virulence and antibiotic resistance in Enterobacteriaceae. MgrB peptide can be produced and secreted by bacteria, and is selectively recognized by a subset of VSNs. Exposure to the peptide also stimulates VSNs in freely behaving mice and drives innate avoidance. Our data shows that Fpr3 is required for neuronal detection and avoidance of peptides derived from a conserved master virulence regulator of enteric bacteria.

Suggested Citation

  • Bernd Bufe & Yannick Teuchert & Andreas Schmid & Martina Pyrski & Anabel Pérez-Gómez & Janina Eisenbeis & Thomas Timm & Tomohiro Ishii & Günter Lochnit & Markus Bischoff & Peter Mombaerts & Trese Lein, 2019. "Bacterial MgrB peptide activates chemoreceptor Fpr3 in mouse accessory olfactory system and drives avoidance behaviour," Nature Communications, Nature, vol. 10(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-12842-x
    DOI: 10.1038/s41467-019-12842-x
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-019-12842-x
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-019-12842-x?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-12842-x. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.