IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v10y2019i1d10.1038_s41467-019-12832-z.html
   My bibliography  Save this article

ZEB1/NuRD complex suppresses TBC1D2b to stimulate E-cadherin internalization and promote metastasis in lung cancer

Author

Listed:
  • Roxsan Manshouri

    (The University of Texas MD Anderson Cancer Center
    The University of Texas MD Anderson Cancer Center)

  • Etienne Coyaud

    (University of Toronto)

  • Samrat T. Kundu

    (The University of Texas MD Anderson Cancer Center
    The University of Texas MD Anderson Cancer Center)

  • David H. Peng

    (The University of Texas MD Anderson Cancer Center
    The University of Texas MD Anderson Cancer Center)

  • Sabrina A. Stratton

    (The University of Texas MD Anderson Cancer Center)

  • Kendra Alton

    (The University of Texas MD Anderson Cancer Center)

  • Rakhee Bajaj

    (The University of Texas MD Anderson Cancer Center
    The University of Texas MD Anderson Cancer Center)

  • Jared J. Fradette

    (The University of Texas MD Anderson Cancer Center
    The University of Texas MD Anderson Cancer Center)

  • Rosalba Minelli

    (The University of Texas MD Anderson Cancer Center)

  • Michael D. Peoples

    (The University of Texas MD Anderson Cancer Center)

  • Alessandro Carugo

    (The University of Texas MD Anderson Cancer Center)

  • Fengju Chen

    (Baylor College of Medicine)

  • Christopher Bristow

    (The University of Texas MD Anderson Cancer Center)

  • Jeffrey J. Kovacs

    (The University of Texas MD Anderson Cancer Center)

  • Michelle C. Barton

    (The University of Texas MD Anderson Cancer Center)

  • Tim Heffernan

    (The University of Texas MD Anderson Cancer Center)

  • Chad J. Creighton

    (Baylor College of Medicine)

  • Brian Raught

    (University of Toronto)

  • Don L. Gibbons

    (The University of Texas MD Anderson Cancer Center
    The University of Texas MD Anderson Cancer Center)

Abstract

Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related death worldwide, due in part to the propensity of lung cancer to metastasize. Aberrant epithelial-to-mesenchymal transition (EMT) is a proposed model for the initiation of metastasis. During EMT cell-cell adhesion is reduced allowing cells to dissociate and invade. Of the EMT-associated transcription factors, ZEB1 uniquely promotes NSCLC disease progression. Here we apply two independent screens, BioID and an Epigenome shRNA dropout screen, to define ZEB1 interactors that are critical to metastatic NSCLC. We identify the NuRD complex as a ZEB1 co-repressor and the Rab22 GTPase-activating protein TBC1D2b as a ZEB1/NuRD complex target. We find that TBC1D2b suppresses E-cadherin internalization, thus hindering cancer cell invasion and metastasis.

Suggested Citation

  • Roxsan Manshouri & Etienne Coyaud & Samrat T. Kundu & David H. Peng & Sabrina A. Stratton & Kendra Alton & Rakhee Bajaj & Jared J. Fradette & Rosalba Minelli & Michael D. Peoples & Alessandro Carugo &, 2019. "ZEB1/NuRD complex suppresses TBC1D2b to stimulate E-cadherin internalization and promote metastasis in lung cancer," Nature Communications, Nature, vol. 10(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-12832-z
    DOI: 10.1038/s41467-019-12832-z
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-019-12832-z
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-019-12832-z?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. M. C. Martinez-Campanario & Marlies Cortés & Alazne Moreno-Lanceta & Lu Han & Chiara Ninfali & Verónica Domínguez & María J. Andrés-Manzano & Marta Farràs & Anna Esteve-Codina & Carlos Enrich & Franci, 2023. "Atherosclerotic plaque development in mice is enhanced by myeloid ZEB1 downregulation," Nature Communications, Nature, vol. 14(1), pages 1-21, December.
    2. Akihiko Fukagawa & Natsuko Hama & Yasushi Totoki & Hiromi Nakamura & Yasuhito Arai & Mihoko Saito-Adachi & Akiko Maeshima & Yoshiyuki Matsui & Shinichi Yachida & Tetsuo Ushiku & Tatsuhiro Shibata, 2023. "Genomic and epigenomic integrative subtypes of renal cell carcinoma in a Japanese cohort," Nature Communications, Nature, vol. 14(1), pages 1-15, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-12832-z. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.