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Dietary tryptophan links encephalogenicity of autoreactive T cells with gut microbial ecology

Author

Listed:
  • Jana K. Sonner

    (German Cancer Research Center (DKFZ)
    Heidelberg University
    University Hospital Hamburg-Eppendorf)

  • Melanie Keil

    (German Cancer Research Center (DKFZ))

  • Maren Falk-Paulsen

    (University Kiel)

  • Neha Mishra

    (University Kiel)

  • Ateequr Rehman

    (University Kiel)

  • Magdalena Kramer

    (German Cancer Research Center (DKFZ)
    Heidelberg University)

  • Katrin Deumelandt

    (German Cancer Research Center (DKFZ)
    Heidelberg University
    Immatics Biotechnologies GmbH)

  • Julian Röwe

    (German Cancer Research Center (DKFZ))

  • Khwab Sanghvi

    (German Cancer Research Center (DKFZ)
    Heidelberg University)

  • Lara Wolf

    (German Cancer Research Center (DKFZ)
    Heidelberg University)

  • Anna Landenberg

    (German Cancer Research Center (DKFZ)
    Heidelberg University)

  • Hendrik Wolff

    (Goethe-University Frankfurt)

  • Richa Bharti

    (University Kiel)

  • Iris Oezen

    (German Cancer Research Center (DKFZ))

  • Tobias V. Lanz

    (German Cancer Research Center (DKFZ)
    Stanford University School of Medicine)

  • Florian Wanke

    (Institute for Molecular Medicine
    Roche)

  • Yilang Tang

    (Institute for Molecular Medicine
    Merck KGaA)

  • Ines Brandao

    (University Medical Center of the Johannes Gutenberg University Mainz)

  • Soumya R. Mohapatra

    (German Cancer Research Center (DKFZ))

  • Lisa Epping

    (Department of Neurology with Institute of Translational Neurology)

  • Alexandra Grill

    (University Medical Center of the Johannes Gutenberg University Mainz)

  • Ralph Röth

    (University of Heidelberg)

  • Beate Niesler

    (University of Heidelberg)

  • Sven G. Meuth

    (Department of Neurology with Institute of Translational Neurology)

  • Christiane A. Opitz

    (German Cancer Research Center (DKFZ)
    University Hospital Heidelberg)

  • Jürgen G. Okun

    (CCU Children’s Hospital and Metabolic Center Heidelberg)

  • Christoph Reinhardt

    (University Medical Center of the Johannes Gutenberg University Mainz)

  • Florian C. Kurschus

    (Institute for Molecular Medicine
    Heidelberg University Hospital)

  • Wolfgang Wick

    (German Cancer Research Center (DKFZ))

  • Helge B. Bode

    (Goethe-University Frankfurt)

  • Philip Rosenstiel

    (University Kiel)

  • Michael Platten

    (German Cancer Research Center (DKFZ)
    Heidelberg University)

Abstract

The interaction between the mammalian host and its resident gut microbiota is known to license adaptive immune responses. Nutritional constituents strongly influence composition and functional properties of the intestinal microbial communities. Here, we report that omission of a single essential amino acid - tryptophan – from the diet abrogates CNS autoimmunity in a mouse model of multiple sclerosis. Dietary tryptophan restriction results in impaired encephalitogenic T cell responses and is accompanied by a mild intestinal inflammatory response and a profound phenotypic shift of gut microbiota. Protective effects of dietary tryptophan restriction are abrogated in germ-free mice, but are independent of canonical host sensors of intracellular tryptophan metabolites. We conclude that dietary tryptophan restriction alters metabolic properties of gut microbiota, which in turn have an impact on encephalitogenic T cell responses. This link between gut microbiota, dietary tryptophan and adaptive immunity may help to develop therapeutic strategies for protection from autoimmune neuroinflammation.

Suggested Citation

  • Jana K. Sonner & Melanie Keil & Maren Falk-Paulsen & Neha Mishra & Ateequr Rehman & Magdalena Kramer & Katrin Deumelandt & Julian Röwe & Khwab Sanghvi & Lara Wolf & Anna Landenberg & Hendrik Wolff & R, 2019. "Dietary tryptophan links encephalogenicity of autoreactive T cells with gut microbial ecology," Nature Communications, Nature, vol. 10(1), pages 1-14, December.
  • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-12776-4
    DOI: 10.1038/s41467-019-12776-4
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    Cited by:

    1. Nguyen T. Van & Karen Zhang & Rachel M. Wigmore & Anne I. Kennedy & Carolina R. DaSilva & Jialing Huang & Manju Ambelil & Jose H. Villagomez & Gerald J. O’Connor & Randy S. Longman & Miao Cao & Adam E, 2023. "Dietary L-Tryptophan consumption determines the number of colonic regulatory T cells and susceptibility to colitis via GPR15," Nature Communications, Nature, vol. 14(1), pages 1-15, December.

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