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Hyperdirect insula-basal-ganglia pathway and adult-like maturity of global brain responses predict inhibitory control in children

Author

Listed:
  • Weidong Cai

    (Stanford University School of Medicine)

  • Katherine Duberg

    (Stanford University School of Medicine)

  • Aarthi Padmanabhan

    (Stanford University School of Medicine)

  • Rachel Rehert

    (Stanford University School of Medicine)

  • Travis Bradley

    (Stanford University School of Medicine)

  • Victor Carrion

    (Stanford University School of Medicine)

  • Vinod Menon

    (Stanford University School of Medicine
    Stanford University School of Medicine
    Stanford University School of Medicine)

Abstract

Inhibitory control is fundamental to children’s self-regulation and cognitive development. Here we investigate cortical-basal ganglia pathways underlying inhibitory control in children and their adult-like maturity. We first conduct a comprehensive meta-analysis of extant neurodevelopmental studies of inhibitory control and highlight important gaps in the literature. Second, we examine cortical-basal ganglia activation during inhibitory control in children ages 9–12 and demonstrate the formation of an adult-like inhibitory control network by late childhood. Third, we develop a neural maturation index (NMI), which assesses the similarity of brain activation patterns between children and adults, and demonstrate that higher NMI in children predicts better inhibitory control. Fourth, we show that activity in the subthalamic nucleus and its effective connectivity with the right anterior insula predicts children’s inhibitory control. Fifth, we replicate our findings across multiple cohorts. Our findings provide insights into cortical-basal ganglia circuits and global brain organization underlying the development of inhibitory control.

Suggested Citation

  • Weidong Cai & Katherine Duberg & Aarthi Padmanabhan & Rachel Rehert & Travis Bradley & Victor Carrion & Vinod Menon, 2019. "Hyperdirect insula-basal-ganglia pathway and adult-like maturity of global brain responses predict inhibitory control in children," Nature Communications, Nature, vol. 10(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-12756-8
    DOI: 10.1038/s41467-019-12756-8
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    Cited by:

    1. Weidong Cai & Jalil Taghia & Vinod Menon, 2024. "A multi-demand operating system underlying diverse cognitive tasks," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    2. Jai, Tun-Min (Catherine) & Fang, Dan & Bao, Forrest S. & James, Russell N. & Chen, Tianwen & Cai, Weidong, 2021. "Seeing It Is Like Touching It: Unraveling the Effective Product Presentations on Online Apparel Purchase Decisions and Brain Activity (An fMRI Study)," Journal of Interactive Marketing, Elsevier, vol. 53(C), pages 66-79.

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