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Injectable human recombinant collagen matrices limit adverse remodeling and improve cardiac function after myocardial infarction

Author

Listed:
  • Sarah McLaughlin

    (University of Ottawa Heart Institute
    University of Ottawa)

  • Brian McNeill

    (University of Ottawa Heart Institute)

  • James Podrebarac

    (University of Ottawa Heart Institute
    University of Ottawa)

  • Katsuhiro Hosoyama

    (University of Ottawa Heart Institute)

  • Veronika Sedlakova

    (University of Ottawa Heart Institute)

  • Gregory Cron

    (University of Ottawa)

  • David Smyth

    (University of Ottawa Heart Institute)

  • Richard Seymour

    (University of Ottawa Heart Institute)

  • Keshav Goel

    (University of Ottawa Heart Institute)

  • Wenbin Liang

    (University of Ottawa
    University of Ottawa Heart Institute)

  • Katey J. Rayner

    (University of Ottawa Heart Institute
    University of Ottawa)

  • Marc Ruel

    (University of Ottawa Heart Institute
    University of Ottawa)

  • Erik J. Suuronen

    (University of Ottawa Heart Institute
    University of Ottawa)

  • Emilio I. Alarcon

    (University of Ottawa Heart Institute
    University of Ottawa)

Abstract

Despite the success of current therapies for acute myocardial infarction (MI), many patients still develop adverse cardiac remodeling and heart failure. With the growing prevalence of heart failure, a new therapy is needed that can prevent remodeling and support tissue repair. Herein, we report on injectable recombinant human collagen type I (rHCI) and type III (rHCIII) matrices for treating MI. Injecting rHCI or rHCIII matrices in mice during the late proliferative phase post-MI restores the myocardium’s mechanical properties and reduces scar size, but only the rHCI matrix maintains remote wall thickness and prevents heart enlargement. rHCI treatment increases cardiomyocyte and capillary numbers in the border zone and the presence of pro-wound healing macrophages in the ischemic area, while reducing the overall recruitment of bone marrow monocytes. Our findings show functional recovery post-MI using rHCI by promoting a healing environment, cardiomyocyte survival, and less pathological remodeling of the myocardium.

Suggested Citation

  • Sarah McLaughlin & Brian McNeill & James Podrebarac & Katsuhiro Hosoyama & Veronika Sedlakova & Gregory Cron & David Smyth & Richard Seymour & Keshav Goel & Wenbin Liang & Katey J. Rayner & Marc Ruel , 2019. "Injectable human recombinant collagen matrices limit adverse remodeling and improve cardiac function after myocardial infarction," Nature Communications, Nature, vol. 10(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-12748-8
    DOI: 10.1038/s41467-019-12748-8
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    Cited by:

    1. Mao Mao & Xiaoli Qu & Yabo Zhang & Bingsong Gu & Chen Li & Rongzhi Liu & Xiao Li & Hui Zhu & Jiankang He & Dichen Li, 2023. "Leaf-venation-directed cellular alignment for macroscale cardiac constructs with tissue-like functionalities," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    2. Chengkun Zhao & Xing Li & Xiaowen Han & Zhulian Li & Shaoquan Bian & Weinan Zeng & Mingming Ding & Jie Liang & Qing Jiang & Zongke Zhou & Yujiang Fan & Xingdong Zhang & Yong Sun, 2024. "Molecular co-assembled strategy tuning protein conformation for cartilage regeneration," Nature Communications, Nature, vol. 15(1), pages 1-14, December.

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