IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v10y2019i1d10.1038_s41467-019-12719-z.html
   My bibliography  Save this article

Towards symmetry driven and nature inspired UV filter design

Author

Listed:
  • Michael D. Horbury

    (University of Warwick, Gibbet Hill
    University of Leeds)

  • Emily L. Holt

    (University of Warwick, Gibbet Hill
    Molecular Analytical Science Centre for Doctoral Training, Senate House, University of Warwick)

  • Louis M. M. Mouterde

    (URD Agro-Biotechnologies Industrielles (ABI), CEBB, AgroParisTech)

  • Patrick Balaguer

    (IRCM, Inserm, Univ Montpellier, ICM)

  • Juan Cebrián

    (Lubrizol Advanced Materials, C/Isaac Peral 17-Pol. Industrial Cami Ral)

  • Laurent Blasco

    (Lubrizol Advanced Materials, C/Isaac Peral 17-Pol. Industrial Cami Ral)

  • Florent Allais

    (URD Agro-Biotechnologies Industrielles (ABI), CEBB, AgroParisTech)

  • Vasilios G. Stavros

    (University of Warwick, Gibbet Hill)

Abstract

In plants, sinapate esters offer crucial protection from the deleterious effects of ultraviolet radiation exposure. These esters are a promising foundation for designing UV filters, particularly for the UVA region (400 – 315 nm), where adequate photoprotection is currently lacking. Whilst sinapate esters are highly photostable due to a cis-trans (and vice versa) photoisomerization, the cis-isomer can display increased genotoxicity; an alarming concern for current cinnamate ester-based human sunscreens. To eliminate this potentiality, here we synthesize a sinapate ester with equivalent cis- and trans-isomers. We investigate its photostability through innovative ultrafast spectroscopy on a skin mimic, thus modelling the as close to true environment of sunscreen formulas. These studies are complemented by assessing endocrine disruption activity and antioxidant potential. We contest, from our results, that symmetrically functionalized sinapate esters may show exceptional promise as nature-inspired UV filters in next generation sunscreen formulations.

Suggested Citation

  • Michael D. Horbury & Emily L. Holt & Louis M. M. Mouterde & Patrick Balaguer & Juan Cebrián & Laurent Blasco & Florent Allais & Vasilios G. Stavros, 2019. "Towards symmetry driven and nature inspired UV filter design," Nature Communications, Nature, vol. 10(1), pages 1-8, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-12719-z
    DOI: 10.1038/s41467-019-12719-z
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-019-12719-z
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-019-12719-z?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-12719-z. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.