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Mice with hyper-long telomeres show less metabolic aging and longer lifespans

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  • Miguel A. Muñoz-Lorente

    (Spanish National Cancer Centre (CNIO))

  • Alba C. Cano-Martin

    (Spanish National Cancer Centre (CNIO))

  • Maria A. Blasco

    (Spanish National Cancer Centre (CNIO))

Abstract

Short telomeres trigger age-related pathologies and shorter lifespans in mice and humans. In the past, we generated mouse embryonic (ES) cells with longer telomeres than normal (hyper-long telomeres) in the absence of genetic manipulations, which contributed to all mouse tissues. To address whether hyper-long telomeres have deleterious effects, we generated mice in which 100% of their cells are derived from hyper-long telomere ES cells. We observe that these mice have longer telomeres and less DNA damage with aging. Hyper-long telomere mice are lean and show low cholesterol and LDL levels, as well as improved glucose and insulin tolerance. Hyper-long telomere mice also have less incidence of cancer and an increased longevity. These findings demonstrate that longer telomeres than normal in a given species are not deleterious but instead, show beneficial effects.

Suggested Citation

  • Miguel A. Muñoz-Lorente & Alba C. Cano-Martin & Maria A. Blasco, 2019. "Mice with hyper-long telomeres show less metabolic aging and longer lifespans," Nature Communications, Nature, vol. 10(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-12664-x
    DOI: 10.1038/s41467-019-12664-x
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    Cited by:

    1. Betz, Ulrich A.K. & Arora, Loukik & Assal, Reem A. & Azevedo, Hatylas & Baldwin, Jeremy & Becker, Michael S. & Bostock, Stefan & Cheng, Vinton & Egle, Tobias & Ferrari, Nicola & Schneider-Futschik, El, 2023. "Game changers in science and technology - now and beyond," Technological Forecasting and Social Change, Elsevier, vol. 193(C).

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