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Dual self-assembly of supramolecular peptide nanotubes to provide stabilisation in water

Author

Listed:
  • Julia Y. Rho

    (University of Warwick)

  • Henry Cox

    (University of Manchester)

  • Edward D. H. Mansfield

    (University of Warwick)

  • Sean H. Ellacott

    (University of Warwick)

  • Raoul Peltier

    (University of Warwick)

  • Johannes C. Brendel

    (University of Warwick)

  • Matthias Hartlieb

    (University of Warwick)

  • Thomas A. Waigh

    (University of Manchester
    University of Manchester)

  • Sébastien Perrier

    (University of Warwick
    Monash University
    University of Warwick)

Abstract

Self-assembling peptides have the ability to spontaneously aggregate into large ordered structures. The reversibility of the peptide hydrogen bonded supramolecular assembly make them tunable to a host of different applications, although it leaves them highly dynamic and prone to disassembly at the low concentration needed for biological applications. Here we demonstrate that a secondary hydrophobic interaction, near the peptide core, can stabilise the highly dynamic peptide bonds, without losing the vital solubility of the systems in aqueous conditions. This hierarchical self-assembly process can be used to stabilise a range of different β-sheet hydrogen bonded architectures.

Suggested Citation

  • Julia Y. Rho & Henry Cox & Edward D. H. Mansfield & Sean H. Ellacott & Raoul Peltier & Johannes C. Brendel & Matthias Hartlieb & Thomas A. Waigh & Sébastien Perrier, 2019. "Dual self-assembly of supramolecular peptide nanotubes to provide stabilisation in water," Nature Communications, Nature, vol. 10(1), pages 1-9, December.
  • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-12586-8
    DOI: 10.1038/s41467-019-12586-8
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