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Anatomy and function of the vertebral column lymphatic network in mice

Author

Listed:
  • Laurent Jacob

    (Université Pierre et Marie Curie Paris 06 UMRS1127, Sorbonne Université, Institut du Cerveau et de la Moelle Epinière)

  • Ligia Simoes Braga Boisserand

    (Yale University School of Medicine)

  • Luiz Henrique Medeiros Geraldo

    (INSERM U970, Paris Cardiovascular Research Center
    Federal University of Rio de Janeiro)

  • Jose Brito Neto

    (Université Pierre et Marie Curie Paris 06 UMRS1127, Sorbonne Université, Institut du Cerveau et de la Moelle Epinière
    Federal University of Rio de Janeiro)

  • Thomas Mathivet

    (INSERM U970, Paris Cardiovascular Research Center)

  • Salli Antila

    (University of Helsinki)

  • Besma Barka

    (Université Pierre et Marie Curie Paris 06 UMRS1127, Sorbonne Université, Institut du Cerveau et de la Moelle Epinière)

  • Yunling Xu

    (INSERM U970, Paris Cardiovascular Research Center)

  • Jean-Mickael Thomas

    (Ecole Nationale Supérieure d’Art de la Villa Arson)

  • Juliette Pestel

    (Université Pierre et Marie Curie Paris 06 UMRS1127, Sorbonne Université, Institut du Cerveau et de la Moelle Epinière)

  • Marie-Stéphane Aigrot

    (Université Pierre et Marie Curie Paris 06 UMRS1127, Sorbonne Université, Institut du Cerveau et de la Moelle Epinière)

  • Eric Song

    (Yale University School of Medicine)

  • Harri Nurmi

    (University of Helsinki)

  • Seyoung Lee

    (Yale University School of Medicine)

  • Kari Alitalo

    (University of Helsinki)

  • Nicolas Renier

    (Université Pierre et Marie Curie Paris 06 UMRS1127, Sorbonne Université, Institut du Cerveau et de la Moelle Epinière)

  • Anne Eichmann

    (INSERM U970, Paris Cardiovascular Research Center
    Yale University School of Medicine)

  • Jean-Leon Thomas

    (Université Pierre et Marie Curie Paris 06 UMRS1127, Sorbonne Université, Institut du Cerveau et de la Moelle Epinière
    Yale University School of Medicine)

Abstract

Cranial lymphatic vessels (LVs) are involved in the transport of fluids, macromolecules and central nervous system (CNS) immune responses. Little information about spinal LVs is available, because these delicate structures are embedded within vertebral tissues and difficult to visualize using traditional histology. Here we show an extended vertebral column LV network using three-dimensional imaging of decalcified iDISCO+-clarified spine segments. Vertebral LVs connect to peripheral sensory and sympathetic ganglia and form metameric vertebral circuits connecting to lymph nodes and the thoracic duct. They drain the epidural space and the dura mater around the spinal cord and associate with leukocytes. Vertebral LVs remodel extensively after spinal cord injury and VEGF-C-induced vertebral lymphangiogenesis exacerbates the inflammatory responses, T cell infiltration and demyelination following focal spinal cord lesion. Therefore, vertebral LVs add to skull meningeal LVs as gatekeepers of CNS immunity and may be potential targets to improve the maintenance and repair of spinal tissues.

Suggested Citation

  • Laurent Jacob & Ligia Simoes Braga Boisserand & Luiz Henrique Medeiros Geraldo & Jose Brito Neto & Thomas Mathivet & Salli Antila & Besma Barka & Yunling Xu & Jean-Mickael Thomas & Juliette Pestel & M, 2019. "Anatomy and function of the vertebral column lymphatic network in mice," Nature Communications, Nature, vol. 10(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-12568-w
    DOI: 10.1038/s41467-019-12568-w
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