IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v10y2019i1d10.1038_s41467-019-12545-3.html
   My bibliography  Save this article

In vivo engineered extracellular matrix scaffolds with instructive niches for oriented tissue regeneration

Author

Listed:
  • Meifeng Zhu

    (Nankai University
    Stevens Institute of Technology
    Tianjin Medical University)

  • Wen Li

    (Nankai University)

  • Xianhao Dong

    (Nankai University)

  • Xingyu Yuan

    (Nankai University)

  • Adam C. Midgley

    (Nankai University)

  • Hong Chang

    (Nankai University)

  • Yuhao Wang

    (Stevens Institute of Technology)

  • Haoyu Wang

    (Stevens Institute of Technology)

  • Kai Wang

    (Nankai University)

  • Peter X. Ma

    (University of Michigan)

  • Hongjun Wang

    (Stevens Institute of Technology)

  • Deling Kong

    (Nankai University
    Tianjin Medical University)

Abstract

Implanted scaffolds with inductive niches can facilitate the recruitment and differentiation of host cells, thereby enhancing endogenous tissue regeneration. Extracellular matrix (ECM) scaffolds derived from cultured cells or natural tissues exhibit superior biocompatibility and trigger favourable immune responses. However, the lack of hierarchical porous structure fails to provide cells with guidance cues for directional migration and spatial organization, and consequently limit the morpho-functional integration for oriented tissues. Here, we engineer ECM scaffolds with parallel microchannels (ECM-C) by subcutaneous implantation of sacrificial templates, followed by template removal and decellularization. The advantages of such ECM-C scaffolds are evidenced by close regulation of in vitro cell activities, and enhanced cell infiltration and vascularization upon in vivo implantation. We demonstrate the versatility and flexibility of these scaffolds by regenerating vascularized and innervated neo-muscle, vascularized neo-nerve and pulsatile neo-artery with functional integration. This strategy has potential to yield inducible biomaterials with applications across tissue engineering and regenerative medicine.

Suggested Citation

  • Meifeng Zhu & Wen Li & Xianhao Dong & Xingyu Yuan & Adam C. Midgley & Hong Chang & Yuhao Wang & Haoyu Wang & Kai Wang & Peter X. Ma & Hongjun Wang & Deling Kong, 2019. "In vivo engineered extracellular matrix scaffolds with instructive niches for oriented tissue regeneration," Nature Communications, Nature, vol. 10(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-12545-3
    DOI: 10.1038/s41467-019-12545-3
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-019-12545-3
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-019-12545-3?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Yi Li & Siyang Liu & Jingjing Zhang & Yumeng Wang & Hongjiang Lu & Yuexi Zhang & Guangzhou Song & Fanhua Niu & Yufan Shen & Adam C. Midgley & Wen Li & Deling Kong & Meifeng Zhu, 2024. "Elastic porous microspheres/extracellular matrix hydrogel injectable composites releasing dual bio-factors enable tissue regeneration," Nature Communications, Nature, vol. 15(1), pages 1-21, December.
    2. Lingchi Kong & Xin Gao & Xiangyun Yao & Haijiao Xie & Qinglin Kang & Wei Sun & Zhengwei You & Yun Qian & Cunyi Fan, 2024. "Multilevel neurium-mimetic individualized graft via additive manufacturing for efficient tissue repair," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-12545-3. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.