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The rostroventral part of the thalamic reticular nucleus modulates fear extinction

Author

Listed:
  • Joon-Hyuk Lee

    (Institute for Basic Science (IBS))

  • Charles-Francois V. Latchoumane

    (Institute for Basic Science (IBS))

  • Jungjoon Park

    (Institute for Basic Science (IBS)
    Korea Advanced Institute of Science and Technology (KAIST))

  • Jinhyun Kim

    (Korea Institute of Science and Technology)

  • Jaeseung Jeong

    (Korea Advanced Institute of Science and Technology (KAIST))

  • Kwang-Hyung Lee

    (Korea Advanced Institute of Science and Technology (KAIST))

  • Hee-Sup Shin

    (Institute for Basic Science (IBS))

Abstract

The thalamus has been implicated in fear extinction, yet the role of the thalamic reticular nucleus (TRN) in this process remains unclear. Here, in mice, we show that the rostroventral part of the TRN (TRNrv) is critically involved in the extinction of tone-dependent fear memory. Optogenetic excitation of TRNrv neurons during extinction learning dramatically facilitated, whereas the inhibition disrupted, the fear extinction. Single unit recordings demonstrated that TRNrv neurons selectively respond to conditioned stimuli but not to neutral stimuli. TRNrv neurons suppressed the spiking activity of the medial part of the dorsal midline thalamus (dMTm), and a blockade of this inhibitory pathway disrupted fear extinction. Finally, we found that the suppression of dMTm projections to the central amygdala promotes fear extinction, and TRNrv neurons have direct connections to this pathway. Our results uncover a previously unknown function of the TRN and delineate the neural circuit for thalamic control of fear memory.

Suggested Citation

  • Joon-Hyuk Lee & Charles-Francois V. Latchoumane & Jungjoon Park & Jinhyun Kim & Jaeseung Jeong & Kwang-Hyung Lee & Hee-Sup Shin, 2019. "The rostroventral part of the thalamic reticular nucleus modulates fear extinction," Nature Communications, Nature, vol. 10(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-12496-9
    DOI: 10.1038/s41467-019-12496-9
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    Cited by:

    1. Jun Ma & John J. O’Malley & Malaz Kreiker & Yan Leng & Isbah Khan & Morgan Kindel & Mario A. Penzo, 2024. "Convergent direct and indirect cortical streams shape avoidance decisions in mice via the midline thalamus," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

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