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Sustained elevation of MG53 in the bloodstream increases tissue regenerative capacity without compromising metabolic function

Author

Listed:
  • Zehua Bian

    (The Ohio State University)

  • Qiang Wang

    (The Ohio State University)

  • Xinyu Zhou

    (The Ohio State University)

  • Tao Tan

    (The Ohio State University)

  • Ki Ho Park

    (The Ohio State University)

  • H. Fritz Kramer

    (GlaxoSmithKline, Inc.)

  • Alan McDougal

    (GlaxoSmithKline, Inc.)

  • Nicholas J. Laping

    (Novel Human Genetics Research Unit, GlaxoSmithKline, Inc.)

  • Sanjay Kumar

    (Novel Human Genetics Research Unit, GlaxoSmithKline, Inc.)

  • T. M. Ayodele Adesanya

    (The Ohio State University)

  • Matthew Sermersheim

    (The Ohio State University)

  • Frank Yi

    (The Ohio State University)

  • Xinxin Wang

    (The First Affiliated Hospital of Zhengzhou University)

  • Junwei Wu

    (The First Affiliated Hospital of Zhengzhou University)

  • Kristyn Gumpper

    (The Ohio State University)

  • Qiwei Jiang

    (The Ohio State University)

  • Duofen He

    (The Third Military Medical University)

  • Pei-Hui Lin

    (The Ohio State University)

  • Haichang Li

    (The Ohio State University)

  • Fangxia Guan

    (School of Life Sciences, Zhengzhou University)

  • Jingsong Zhou

    (University of Texas at Arlington)

  • Mark J. Kohr

    (Johns Hopkins University)

  • Chunyu Zeng

    (The Third Military Medical University)

  • Hua Zhu

    (The Ohio State University)

  • Jianjie Ma

    (The Ohio State University)

Abstract

MG53 is a muscle-specific TRIM-family protein that presides over the cell membrane repair response. Here, we show that MG53 present in blood circulation acts as a myokine to facilitate tissue injury-repair and regeneration. Transgenic mice with sustained elevation of MG53 in the bloodstream (tPA-MG53) have a healthier and longer life-span when compared with littermate wild type mice. The tPA-MG53 mice show normal glucose handling and insulin signaling in skeletal muscle, and sustained elevation of MG53 in the bloodstream does not have a deleterious impact on db/db mice. More importantly, the tPA-MG53 mice display remarkable dermal wound healing capacity, enhanced muscle performance, and improved injury-repair and regeneration. Recombinant human MG53 protein protects against eccentric contraction-induced acute and chronic muscle injury in mice. Our findings highlight the myokine function of MG53 in tissue protection and present MG53 as an attractive biological reagent for regenerative medicine without interference with glucose handling in the body.

Suggested Citation

  • Zehua Bian & Qiang Wang & Xinyu Zhou & Tao Tan & Ki Ho Park & H. Fritz Kramer & Alan McDougal & Nicholas J. Laping & Sanjay Kumar & T. M. Ayodele Adesanya & Matthew Sermersheim & Frank Yi & Xinxin Wan, 2019. "Sustained elevation of MG53 in the bloodstream increases tissue regenerative capacity without compromising metabolic function," Nature Communications, Nature, vol. 10(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-12483-0
    DOI: 10.1038/s41467-019-12483-0
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    Cited by:

    1. Haiwen Li & Peipei Wang & Chen Zhang & Yuanbojiao Zuo & Yuan Zhou & Renzhi Han, 2023. "Defective BVES-mediated feedback control of cAMP in muscular dystrophy," Nature Communications, Nature, vol. 14(1), pages 1-14, December.

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