IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v10y2019i1d10.1038_s41467-019-12413-0.html
   My bibliography  Save this article

A fiber-deprived diet disturbs the fine-scale spatial architecture of the murine colon microbiome

Author

Listed:
  • Alessandra Riva

    (University of Vienna)

  • Orest Kuzyk

    (University of Vienna)

  • Erica Forsberg

    (Scripps Center for Metabolomics and Mass Spectrometry
    San Diego State University)

  • Gary Siuzdak

    (Scripps Center for Metabolomics and Mass Spectrometry)

  • Carina Pfann

    (University of Vienna)

  • Craig Herbold

    (University of Vienna)

  • Holger Daims

    (University of Vienna)

  • Alexander Loy

    (University of Vienna)

  • Benedikt Warth

    (Scripps Center for Metabolomics and Mass Spectrometry
    University of Vienna)

  • David Berry

    (University of Vienna
    Joint Microbiome Facility of the Medical University of Vienna and the University of Vienna)

Abstract

Compartmentalization of the gut microbiota is thought to be important to system function, but the extent of spatial organization in the gut ecosystem remains poorly understood. Here, we profile the murine colonic microbiota along longitudinal and lateral axes using laser capture microdissection. We found fine-scale spatial structuring of the microbiota marked by gradients in composition and diversity along the length of the colon. Privation of fiber reduces the diversity of the microbiota and disrupts longitudinal and lateral gradients in microbiota composition. Both mucus-adjacent and luminal communities are influenced by the absence of dietary fiber, with the loss of a characteristic distal colon microbiota and a reduction in the mucosa-adjacent community, concomitant with depletion of the mucus layer. These results indicate that diet has not only global but also local effects on the composition of the gut microbiota, which may affect function and resilience differently depending on location.

Suggested Citation

  • Alessandra Riva & Orest Kuzyk & Erica Forsberg & Gary Siuzdak & Carina Pfann & Craig Herbold & Holger Daims & Alexander Loy & Benedikt Warth & David Berry, 2019. "A fiber-deprived diet disturbs the fine-scale spatial architecture of the murine colon microbiome," Nature Communications, Nature, vol. 10(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-12413-0
    DOI: 10.1038/s41467-019-12413-0
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-019-12413-0
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-019-12413-0?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-12413-0. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.