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Time elapsed between Zika and dengue virus infections affects antibody and T cell responses

Author

Listed:
  • Erick X. Pérez-Guzmán

    (University of Puerto Rico-Medical Sciences Campus
    Takeda Vaccines Inc)

  • Petraleigh Pantoja

    (University of Puerto Rico-Medical Sciences Campus
    University of Puerto Rico-Medical Sciences Campus)

  • Crisanta Serrano-Collazo

    (University of Puerto Rico-Medical Sciences Campus)

  • Mariah A. Hassert

    (Saint Louis University School of Medicine)

  • Alexandra Ortiz-Rosa

    (University of Puerto Rico-Río Piedras Campus)

  • Idia V. Rodríguez

    (University of Puerto Rico-Medical Sciences Campus)

  • Luis Giavedoni

    (Texas Biomedical Research Institute)

  • Vida Hodara

    (Texas Biomedical Research Institute)

  • Laura Parodi

    (Texas Biomedical Research Institute)

  • Lorna Cruz

    (University of Puerto Rico-Medical Sciences Campus
    University of Puerto Rico-Medical Sciences Campus)

  • Teresa Arana

    (University of Puerto Rico-Medical Sciences Campus
    University of Puerto Rico-Medical Sciences Campus)

  • Laura J. White

    (University of North Carolina-Chapel Hill)

  • Melween I. Martínez

    (University of Puerto Rico-Medical Sciences Campus
    University of Puerto Rico-Medical Sciences Campus)

  • Daniela Weiskopf

    (La Jolla Institute for Immunology)

  • James D. Brien

    (Saint Louis University School of Medicine)

  • Aravinda Silva

    (University of North Carolina-Chapel Hill)

  • Amelia K. Pinto

    (Saint Louis University School of Medicine)

  • Carlos A. Sariol

    (University of Puerto Rico-Medical Sciences Campus
    University of Puerto Rico-Medical Sciences Campus
    University of Puerto Rico-Medical Sciences Campus)

Abstract

Zika virus (ZIKV) and dengue virus (DENV) are co-endemic in many parts of the world, but the impact of ZIKV infection on subsequent DENV infection is not well understood. Here we show in rhesus macaques that the time elapsed after ZIKV infection affects the immune response to DENV infection. We show that previous ZIKV exposure increases the magnitude of the antibody and T cell responses against DENV. The time interval between ZIKV and subsequent DENV infection further affects the immune response. A mid-convalescent period of 10 months after ZIKV infection results in higher and more durable antibody and T cell responses to DENV infection than a short period of 2 months. In contrast, previous ZIKV infection does not affect DENV viremia or pro-inflammatory status. Collectively, we find no evidence of a detrimental effect of ZIKV immunity in a subsequent DENV infection. This supports the implementation of ZIKV vaccines that could also boost immunity against future DENV epidemics.

Suggested Citation

  • Erick X. Pérez-Guzmán & Petraleigh Pantoja & Crisanta Serrano-Collazo & Mariah A. Hassert & Alexandra Ortiz-Rosa & Idia V. Rodríguez & Luis Giavedoni & Vida Hodara & Laura Parodi & Lorna Cruz & Teresa, 2019. "Time elapsed between Zika and dengue virus infections affects antibody and T cell responses," Nature Communications, Nature, vol. 10(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-12295-2
    DOI: 10.1038/s41467-019-12295-2
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    Cited by:

    1. Ellen Young & Boyd Yount & Petraleigh Pantoja & Sandra Henein & Rita M. Meganck & Jennifer McBride & Jennifer E. Munt & Thomas J. Baric & Deanna Zhu & Trevor Scobey & Stephanie Dong & Longping V. Tse , 2023. "A live dengue virus vaccine carrying a chimeric envelope glycoprotein elicits dual DENV2-DENV4 serotype-specific immunity," Nature Communications, Nature, vol. 14(1), pages 1-12, December.

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