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Associations of autozygosity with a broad range of human phenotypes

Author

Listed:
  • David W Clark

    (University of Edinburgh)

  • Yukinori Okada

    (Osaka University Graduate School of Medicine, Suita
    RIKEN Center for Integrative Medical Sciences
    Osaka University, Suita)

  • Kristjan H S Moore

    (deCODE genetics/Amgen Inc.)

  • Dan Mason

    (Bradford Teaching Hospitals NHS Trust)

  • Nicola Pirastu

    (University of Edinburgh)

  • Ilaria Gandin

    (Area Science Park
    University of Trieste)

  • Hannele Mattsson

    (National Institute for Health and Welfare
    University of Helsinki)

  • Catriona L K Barnes

    (University of Edinburgh)

  • Kuang Lin

    (University of Oxford)

  • Jing Hua Zhao

    (University of Cambridge School of Clinical Medicine
    University of Cambridge)

  • Patrick Deelen

    (University Medical Centre Groningen, University of Groningen, Groningen, the Netherlands, Groningen)

  • Rebecca Rohde

    (University of North Carolina)

  • Claudia Schurmann

    (Ichan School of Medicine at Mount Sinai)

  • Xiuqing Guo

    (LABioMed at Harbor-UCLA Medical Center, Torrance)

  • Franco Giulianini

    (Brigham and Women’s Hospital)

  • Weihua Zhang

    (Imperial College London
    Ealing Hospital, Middlesex)

  • Carolina Medina-Gomez

    (Erasmus University Medical Center
    Erasmus University Medical Center
    The Generation R Study Group, Erasmus University Medical Center)

  • Robert Karlsson

    (Karolinska Institutet)

  • Yanchun Bao

    (Institute for Social and Economic Research, University of Essex)

  • Traci M Bartz

    (University of Washington)

  • Clemens Baumbach

    (Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health)

  • Ginevra Biino

    (Institute of Molecular Genetics, National Research Council of Italy)

  • Matthew J Bixley

    (University of Otago)

  • Marco Brumat

    (University of Trieste)

  • Jin-Fang Chai

    (National University of Singapore, Singapore)

  • Tanguy Corre

    (University of Lausanne
    University of Lausanne
    Swiss Institute of Bioinformatics)

  • Diana L Cousminer

    (Children’s Hospital of Philadelphia
    University of Pennsylvania)

  • Annelot M Dekker

    (University Medical Centre Utrecht, Utrecht University)

  • David A Eccles

    (Institute of Health and Biomedical Innovation, Queensland University of Technology
    Malaghan Institute of Medical Research)

  • Kristel R Eijk

    (University Medical Centre Utrecht, Utrecht University)

  • Christian Fuchsberger

    (Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck)

  • He Gao

    (Imperial College London
    Imperial College London)

  • Marine Germain

    (Sorbonne Universités
    ICAN Institute for Cardiometabolism and Nutrition)

  • Scott D Gordon

    (QIMR Berghofer Institute of Medical Research)

  • Hugoline G Haan

    (Leiden University Medical Center)

  • Sarah E Harris

    (University of Edinburgh
    Institute of Genetics & Molecular Medicine, University of Edinburgh)

  • Edith Hofer

    (Medical University of Graz
    Institute of Medical Informatics, Statistics and Documentation, Medical University of Graz)

  • Alicia Huerta-Chagoya

    (CONACyT, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán)

  • Catherine Igartua

    (University of Chicago)

  • Iris E Jansen

    (Vrije Universiteit Amsterdam
    VU University Medical Center, Amsterdam Neuroscience)

  • Yucheng Jia

    (LABioMed at Harbor-UCLA Medical Center, Torrance)

  • Tim Kacprowski

    (Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald
    TUM School of Life Sciences Weihenstephan, Technical University of Munich)

  • Torgny Karlsson

    (Uppsala University)

  • Marcus E Kleber

    (Heidelberg University)

  • Shengchao Alfred Li

    (Leidos Biomedical Research, Inc., Frederick National Lab for Cancer Research)

  • Ruifang Li-Gao

    (Leiden University Medical Center)

  • Anubha Mahajan

    (University of Oxford)

  • Koichi Matsuda

    (Graduate school of Frontier Sciences, The University of Tokyo)

  • Karina Meidtner

    (German Institute of Human Nutrition Potsdam-Rehbruecke
    German Center for Diabetes Research (DZD))

  • Weihua Meng

    (Medical Research Institute, Ninewells Hospital and School of Medicine, University of Dundee)

  • May E Montasser

    (University of Maryland, School of Medicine
    University of Maryland, School of Medicine)

  • Peter J Most

    (University of Groningen, University Medical Center Groningen)

  • Matthias Munz

    (Institute for Cardiogenetics, University of Lübeck
    partner site Hamburg/Lübeck/Kiel
    University Heart Center Luebeck
    Charité – University Medicine Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute for Dental and Craniofacial Sciences, Department of Periodontology and Synoptic Dentistry)

  • Teresa Nutile

    (Institute of Genetics and Biophysics A. Buzzati-Traverso - CNR)

  • Teemu Palviainen

    (Finnish Institute for Molecular Medicine, University of Helsinki)

  • Gauri Prasad

    (Genomics and Molecular Medicine Unit, CSIR-Institute of Genomics and Integrative Biology)

  • Rashmi B Prasad

    (Lund University Diabetes Centre, Lund University, Skåne University Hospital)

  • Tallapragada Divya Sri Priyanka

    (CSIR-Centre for Cellular and Molecular Biology)

  • Federica Rizzi

    (ePhood Scientific Unit, ePhood SRL
    University of Milano)

  • Erika Salvi

    (University of Milano
    IRCCS Foundation Carlo Besta Neurological Institute)

  • Bishwa R Sapkota

    (University of Oklahoma Health Sciences Center)

  • Daniel Shriner

    (National Human Genome Research Institute, National Institutes of Health)

  • Line Skotte

    (Statens Serum Institut)

  • Melissa C Smart

    (Institute for Social and Economic Research, University of Essex)

  • Albert Vernon Smith

    (Icelandic Heart Association
    University of Iceland)

  • Ashley Spek

    (Erasmus University Medical Center)

  • Cassandra N Spracklen

    (University of North Carolina)

  • Rona J Strawbridge

    (Institute of Health and Wellbeing, University of Glasgow
    Karolinska Institutet)

  • Salman M Tajuddin

    (National Institute on Aging, National Institutes of Health)

  • Stella Trompet

    (Leiden University Medical Center
    Leiden University Medical Center)

  • Constance Turman

    (Harvard T.H. Chan School of Public Health
    Program in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health)

  • Niek Verweij

    (University of Groningen, University Medical Center Groningen, Department of Cardiology, Ther Netherlands)

  • Clara Viberti

    (University of Turin, Italy)

  • Lihua Wang

    (Washington University School of Medicine)

  • Helen R Warren

    (Barts and The London School of Medicine and Dentistry, Queen Mary University of London
    William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London)

  • Robyn E Wootton

    (MRC Integrative Epidemiology Unit at the University of Bristol
    School of Psychological Science, University of Bristol)

  • Lisa R Yanek

    (Johns Hopkins University School of Medicine)

  • Jie Yao

    (LABioMed at Harbor-UCLA Medical Center, Torrance)

  • Noha A Yousri

    (Weill Cornell Medicine Qatar
    Alexandria University)

  • Wei Zhao

    (University of Michigan)

  • Adebowale A Adeyemo

    (National Human Genome Research Institute, National Institutes of Health)

  • Saima Afaq

    (Imperial College London)

  • Carlos Alberto Aguilar-Salinas

    (Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
    Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud)

  • Masato Akiyama

    (RIKEN Center for Integrative Medical Sciences
    Graduate School of Medical Sciences, Kyushu University, Fukuoka)

  • Matthew L Albert

    (Immunobiology of Dendritic Cells, Institut Pasteur
    Inserm U1223
    Institut Pasteur
    Genentech Inc)

  • Matthew A Allison

    (UC San Diego School of Medicine)

  • Maris Alver

    (University of Tartu, University of Tartu)

  • Tin Aung

    (Singapore Eye Research Institute, Singapore National Eye Centre, Singapore
    Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore
    Yong Loo Lin School of Medicine, National University of Singapore, Singapore)

  • Fereidoun Azizi

    (Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences)

  • Amy R Bentley

    (National Human Genome Research Institute, National Institutes of Health)

  • Heiner Boeing

    (German Institute of Human Nutrition Potsdam-Rehbruecke)

  • Eric Boerwinkle

    (UTHealth School of Public Health, University of Texas)

  • Judith B Borja

    (USC-Office of Population Studies Foundation, Inc., Department of Nutrition and Dietetics, Talamban, University of San Carlos)

  • Gert J Borst

    (University Medical Center Utrecht, University of Utrecht, Utrecht)

  • Erwin P Bottinger

    (Ichan School of Medicine at Mount Sinai
    Hasso Plattner Institute, Universität Potsdam)

  • Linda Broer

    (Erasmus University Medical Center)

  • Harry Campbell

    (University of Edinburgh)

  • Stephen Chanock

    (National Cancer Institute, National Institutes of Health)

  • Miao-Li Chee

    (Singapore Eye Research Institute, Singapore National Eye Centre, Singapore)

  • Guanjie Chen

    (National Human Genome Research Institute, National Institutes of Health)

  • Yii-Der I Chen

    (LABioMed at Harbor-UCLA Medical Center, Torrance)

  • Zhengming Chen

    (University of Oxford)

  • Yen-Feng Chiu

    (Institute of Population Health Sciences, National Health Research Institutes)

  • Massimiliano Cocca

    (Institute for Maternal and Child Health - IRCCS Burlo Garofolo)

  • Francis S Collins

    (National Human Genome Research Institute, National Institutes of Health)

  • Maria Pina Concas

    (Institute for Maternal and Child Health - IRCCS Burlo Garofolo)

  • Janie Corley

    (University of Edinburgh
    University of Edinburgh)

  • Giovanni Cugliari

    (University of Turin, Italy)

  • Rob M Dam

    (National University of Singapore, Singapore
    Yong Loo Lin School of Medicine, National University of Singapore
    Harvard T.H. Chan School of Public Health)

  • Anna Damulina

    (Medical University of Graz)

  • Maryam S Daneshpour

    (Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences)

  • Felix R Day

    (University of Cambridge School of Clinical Medicine)

  • Graciela E Delgado

    (Heidelberg University)

  • Klodian Dhana

    (Erasmus University Medical Center
    Harvard T.H. Chan School of Public Health
    Rush University Medical Center)

  • Alexander S F Doney

    (Molecular and Clinical Medicine, University of Dundee)

  • Marcus Dörr

    (University Medicine Greifswald
    partner site Greifswald)

  • Ayo P Doumatey

    (National Human Genome Research Institute, National Institutes of Health)

  • Nduna Dzimiri

    (King Faisal Specialist Hospital and Research Center)

  • S Sunna Ebenesersdóttir

    (deCODE genetics/Amgen Inc.
    University of Iceland)

  • Joshua Elliott

    (Imperial College London)

  • Paul Elliott

    (Imperial College London
    Imperial College London
    National Institute for Health Research Imperial Biomedical Research Centre, Imperial College Healthcare NHS Trust and Imperial College London
    UK Dementia Research Institute (UK DRI) at Imperial College London)

  • Ralf Ewert

    (University Medicine Greifswald)

  • Janine F Felix

    (Erasmus University Medical Center
    The Generation R Study Group, Erasmus University Medical Center
    Erasmus University Medical Center)

  • Krista Fischer

    (University of Tartu, University of Tartu)

  • Barry I Freedman

    (Wake Forest School of Medicine)

  • Giorgia Girotto

    (University of Trieste
    Institute for Maternal and Child Health - IRCCS Burlo Garofolo)

  • Anuj Goel

    (University of Oxford
    University of Oxford)

  • Martin Gögele

    (Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck)

  • Mark O Goodarzi

    (Cedars-Sinai Medical Center)

  • Mariaelisa Graff

    (University of North Carolina)

  • Einat Granot-Hershkovitz

    (Hebrew University-Hadassah Medical Center)

  • Francine Grodstein

    (Harvard T.H. Chan School of Public Health)

  • Simonetta Guarrera

    (University of Turin, Italy)

  • Daniel F Gudbjartsson

    (deCODE genetics/Amgen Inc.
    School of Engineering and Natural Sciences, University of Iceland)

  • Kamran Guity

    (Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences)

  • Bjarni Gunnarsson

    (deCODE genetics/Amgen Inc.)

  • Yu Guo

    (Chinese Academy of Medical Sciences)

  • Saskia P Hagenaars

    (University of Edinburgh
    University of Edinburgh
    Institute of Psychiatry, Psychology & Neuroscience, King’s College London)

  • Christopher A Haiman

    (Keck School of Medicine, University of Southern California)

  • Avner Halevy

    (Hebrew University-Hadassah Medical Center)

  • Tamara B Harris

    (National Institute on Aging, National Institutes of Health)

  • Mehdi Hedayati

    (Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences)

  • David A Heel

    (Blizard Institute, Queen Mary University of London)

  • Makoto Hirata

    (Institute of Medical Science, The University of Tokyo)

  • Imo Höfer

    (University Medical Center Utrecht, University of Utrecht, Utrecht)

  • Chao Agnes Hsiung

    (Institute of Population Health Sciences, National Health Research Institutes)

  • Jinyan Huang

    (Shanghai Institute of Hematology, State Key Laboratory Of Medical Genomics, Rui-jin Hospital, Shanghai Jiao Tong University School of Medicine)

  • Yi-Jen Hung

    (Tri-Service General Hospital Songshan branch
    National Defense Medical Center)

  • M Arfan Ikram

    (Erasmus University Medical Center)

  • Anuradha Jagadeesan

    (deCODE genetics/Amgen Inc.
    University of Iceland)

  • Pekka Jousilahti

    (National Institute for Health and Welfare)

  • Yoichiro Kamatani

    (RIKEN Center for Integrative Medical Sciences
    Kyoto University Graduate School of Medicine)

  • Masahiro Kanai

    (Osaka University Graduate School of Medicine, Suita
    RIKEN Center for Integrative Medical Sciences
    Harvard Medical School)

  • Nicola D Kerrison

    (University of Cambridge School of Clinical Medicine)

  • Thorsten Kessler

    (Klinik für Herz- und Kreislauferkrankungen, Technische Universität München)

  • Kay-Tee Khaw

    (University of Cambridge)

  • Chiea Chuen Khor

    (Singapore Eye Research Institute, Singapore National Eye Centre, Singapore
    Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore)

  • Dominique P V Kleijn

    (University Medical Center Utrecht, University of Utrecht, Utrecht)

  • Woon-Puay Koh

    (National University of Singapore, Singapore
    Duke-NUS Medical School)

  • Ivana Kolcic

    (University of Split)

  • Peter Kraft

    (Harvard T.H. Chan School of Public Health)

  • Bernhard K Krämer

    (Heidelberg University)

  • Zoltán Kutalik

    (University of Lausanne
    Swiss Institute of Bioinformatics)

  • Johanna Kuusisto

    (Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland
    Kuopio University Hospital)

  • Claudia Langenberg

    (University of Cambridge School of Clinical Medicine)

  • Lenore J Launer

    (National Institute on Aging, National Institutes of Health)

  • Deborah A Lawlor

    (MRC Integrative Epidemiology Unit at the University of Bristol
    Bristol NIHR Biomedical Research Centre
    Bristol Medical School)

  • I-Te Lee

    (Taichung Veterans General Hospital
    National Yang-Ming University, Taipei, Taiwan
    Chung Shan Medical University, Taichung, Taiwan)

  • Wen-Jane Lee

    (Taichung Veterans General Hospital)

  • Markus M Lerch

    (University Medicine Greifswald)

  • Liming Li

    (Peking University Health Science Centre, Peking University)

  • Jianjun Liu

    (Yong Loo Lin School of Medicine, National University of Singapore
    Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore)

  • Marie Loh

    (Imperial College London
    Agency for Science, Technology and Research, Singapore (A*STAR)
    Yong Loo Lin School of Medicine, National University of Singapore, Singapore)

  • Stephanie J London

    (National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services)

  • Stephanie Loomis

    (Johns Hopkins Bloomberg School of Public Health)

  • Yingchang Lu

    (Ichan School of Medicine at Mount Sinai)

  • Jian’an Luan

    (University of Cambridge School of Clinical Medicine)

  • Reedik Mägi

    (University of Tartu, University of Tartu)

  • Ani W Manichaikul

    (University of Virginia School of Medicine)

  • Paolo Manunta

    (IRCCS San Raffaele Scientific Institute, Università Vita Salute San Raffaele)

  • Gísli Másson

    (deCODE genetics/Amgen Inc.)

  • Nana Matoba

    (RIKEN Center for Integrative Medical Sciences)

  • Xue W Mei

    (University of Oxford)

  • Christa Meisinger

    (Independent Research Group Clinical Epidemiology)

  • Thomas Meitinger

    (Institute of Human Genetics, Helmholtz Zentrum Muenchen
    Institute of Human Genetics, Technical University of Munich
    DZHK (German Center for Cardiovascular Research), partner site Munich Heart Alliance)

  • Massimo Mezzavilla

    (Institute for Maternal and Child Health - IRCCS Burlo Garofolo)

  • Lili Milani

    (Institute of Genomics, University of Tartu)

  • Iona Y Millwood

    (University of Oxford)

  • Yukihide Momozawa

    (RIKEN Center for Integrative Medical Sciences)

  • Amy Moore

    (National Cancer Institute, National Institutes of Health)

  • Pierre-Emmanuel Morange

    (Laboratory of Haematology, La Timone Hospital
    Aix-Marseille University)

  • Hortensia Moreno-Macías

    (Universidad Autónoma Metropolitana)

  • Trevor A Mori

    (The University of Western Australia)

  • Alanna C Morrison

    (The University of Texas Health Science Center at Houston, School of Public Health, Department of Epidemiology, Human Genetics and Environmental Sciences)

  • Taulant Muka

    (Erasmus University Medical Center
    Institute of Social and Preventive Medicine (ISPM), University of Bern)

  • Yoshinori Murakami

    (Institute of Medical Science, The University of Tokyo)

  • Alison D Murray

    (The Institute of Medical Sciences, Aberdeen Biomedical Imaging Centre, University of Aberdeen)

  • Renée Mutsert

    (Leiden University Medical Center)

  • Josyf C Mychaleckyj

    (University of Virginia School of Medicine)

  • Mike A Nalls

    (Laboratory of Neurogenetics
    Data Tecnica International LLC)

  • Matthias Nauck

    (partner site Greifswald
    Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald)

  • Matt J Neville

    (University of Oxford, Headington
    Oxford University Hospitals Trust)

  • Ilja M Nolte

    (University of Groningen, University Medical Center Groningen)

  • Ken K Ong

    (University of Cambridge School of Clinical Medicine
    University of Cambridge School of Clinical Medicine)

  • Lorena Orozco

    (Instituto Nacional de Medicina Genómica)

  • Sandosh Padmanabhan

    (Institute of Cardiovascular and Medical Sciences, University of Glasgow)

  • Gunnar Pálsson

    (deCODE genetics/Amgen Inc.)

  • James S Pankow

    (School of Public Health, University of Minnesota)

  • Cristian Pattaro

    (Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck)

  • Alison Pattie

    (University of Edinburgh)

  • Ozren Polasek

    (University of Split
    Gen-info Ltd, Zagreb, Croatia)

  • Neil Poulter

    (International Centre for Circulatory Health, Imperial College London
    Imperial College London, London)

  • Peter P Pramstaller

    (Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck)

  • Lluis Quintana-Murci

    (Human Evolutionary Genetics Unit, Institut Pasteur
    Centre National de la Recherche Scientifique (CNRS) UMR2000
    Institut Pasteur)

  • Katri Räikkönen

    (University of Helsinki, University of Helsinki)

  • Sarju Ralhan

    (Hero Heart Institute and Dyanand Medical College and Hospital)

  • Dabeeru C Rao

    (Washington University School of Medicine)

  • Wouter Rheenen

    (University Medical Centre Utrecht, Utrecht University)

  • Stephen S Rich

    (University of Virginia School of Medicine)

  • Paul M Ridker

    (Brigham and Women’s Hospital
    Harvard Medical School)

  • Cornelius A Rietveld

    (Erasmus School of Economics, Erasmus University Rotterdam
    Erasmus University Rotterdam Institute for Behavior and Biology, Erasmus University Rotterdam)

  • Antonietta Robino

    (Institute for Maternal and Child Health - IRCCS Burlo Garofolo)

  • Frank J A Rooij

    (Erasmus University Medical Center)

  • Daniela Ruggiero

    (Institute of Genetics and Biophysics A. Buzzati-Traverso - CNR
    IRCCS Neuromed)

  • Yasaman Saba

    (Medical University of Graz)

  • Charumathi Sabanayagam

    (Singapore Eye Research Institute, Singapore National Eye Centre, Singapore
    Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore
    Yong Loo Lin School of Medicine, National University of Singapore, Singapore)

  • Maria Sabater-Lleal

    (Karolinska Institutet
    Institut de Recerca Hospital de la Santa Creu i Sant Pau, IIB-Sant Pau)

  • Cinzia Felicita Sala

    (San Raffaele Research Institute)

  • Veikko Salomaa

    (National Institute for Health and Welfare)

  • Kevin Sandow

    (LABioMed at Harbor-UCLA Medical Center, Torrance)

  • Helena Schmidt

    (Medical University of Graz)

  • Laura J Scott

    (University of Michigan)

  • William R Scott

    (Imperial College London)

  • Bahareh Sedaghati-Khayat

    (Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences)

  • Bengt Sennblad

    (Karolinska Institutet
    National Bioinformatics Infrastructure Sweden, Science for Life Laboratory, Uppsala University, Uppsala)

  • Jessica Setten

    (University Medical Center Utrecht, University of Utrecht, Utrecht)

  • Peter J Sever

    (International Centre for Circulatory Health, Imperial College London)

  • Wayne H-H Sheu

    (National Defense Medical Center
    Taichung Veterans General Hospital
    School of Medicine, National Yang-Ming University
    Institute of Medical Technology, National Chung-Hsing University)

  • Yuan Shi

    (Singapore Eye Research Institute, Singapore National Eye Centre, Singapore)

  • Smeeta Shrestha

    (CSIR-Centre for Cellular and Molecular Biology
    School of Basic and Applied Sciences, Dayananda Sagar University)

  • Sharvari Rahul Shukla

    (Diabetes Unit, KEM Hospital and Research Centre
    Symbiosis Statistical Institute, Symbiosis International University)

  • Jon K Sigurdsson

    (deCODE genetics/Amgen Inc.)

  • Timo Tonis Sikka

    (University of Tartu, University of Tartu)

  • Jai Rup Singh

    (Panjab University)

  • Blair H Smith

    (Ninewells Hospital and Medical School, University of Dundee)

  • Alena Stančáková

    (Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland)

  • Alice Stanton

    (RCSI Molecular & Cellular Therapeutics (MCT), Royal College of Surgeons in Ireland, RCSI Education & Research Centre, Beaumont Hospital)

  • John M Starr

    (University of Edinburgh
    University of Edinburgh)

  • Lilja Stefansdottir

    (deCODE genetics/Amgen Inc.)

  • Leon Straker

    (School of Physiotherapy and Exercise Science, Faculty of Health Sciences, Curtin University)

  • Patrick Sulem

    (deCODE genetics/Amgen Inc.)

  • Gardar Sveinbjornsson

    (deCODE genetics/Amgen Inc.)

  • Morris A Swertz

    (University Medical Centre Groningen, University of Groningen, Groningen, the Netherlands, Groningen)

  • Adele M Taylor

    (University of Edinburgh)

  • Kent D Taylor

    (LABioMed at Harbor-UCLA Medical Center, Torrance)

  • Natalie Terzikhan

    (Erasmus University Medical Center
    Ghent University Hospital)

  • Yih-Chung Tham

    (Singapore Eye Research Institute, Singapore National Eye Centre, Singapore
    Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore)

  • Gudmar Thorleifsson

    (deCODE genetics/Amgen Inc.)

  • Unnur Thorsteinsdottir

    (deCODE genetics/Amgen Inc.
    University of Iceland)

  • Annika Tillander

    (Karolinska Institutet)

  • Russell P Tracy

    (University of Vermont)

  • Teresa Tusié-Luna

    (Instituto de Investigaciones Biomédicas, UNAM
    Unidad De Biología Molecular y Medicina Genómica, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán)

  • Ioanna Tzoulaki

    (Imperial College London
    Imperial College London
    University of Ioannina Medical School)

  • Simona Vaccargiu

    (Institute of Genetic and Biomedical Research - Support Unity, National Research Council of Italy)

  • Jagadish Vangipurapu

    (Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland)

  • Jan H Veldink

    (University Medical Centre Utrecht, Utrecht University)

  • Veronique Vitart

    (Institute of Genetics and Molecular Medicine, University of Edinburgh)

  • Uwe Völker

    (Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald
    partner site Greifswald)

  • Eero Vuoksimaa

    (Institute for Molecular Medicine Finland (FIMM), University of Helsinki)

  • Salma M Wakil

    (King Faisal Specialist Hospital and Research Center)

  • Melanie Waldenberger

    (Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health)

  • Gurpreet S Wander

    (Hero DMC Heart Institute, Dayanand Medical College & Hospital)

  • Ya Xing Wang

    (Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Science Key Lab)

  • Nicholas J Wareham

    (University of Cambridge School of Clinical Medicine)

  • Sarah Wild

    (Usher Institute of Population Health and Informatics, University of Edinburgh)

  • Chittaranjan S Yajnik

    (Diabetes Unit, K.E.M. Hospital Research Centre)

  • Jian-Min Yuan

    (Graduate School of Public Health, University of Pittsburgh)

  • Lingyao Zeng

    (Klinik für Herz- und Kreislauferkrankungen, Technische Universität München)

  • Liang Zhang

    (Singapore Eye Research Institute, Singapore National Eye Centre, Singapore)

  • Jie Zhou

    (National Human Genome Research Institute, National Institutes of Health)

  • Najaf Amin

    (Erasmus University Medical Center)

  • Folkert W Asselbergs

    (University Medical Center Utrecht, University of Utrecht, Utrecht
    Institute of Cardiovascular Science, Faculty of Population Health Sciences, University College London
    Netherlands Heart Institute
    Farr Institute of Health Informatics Research and Institute of Health Informatics, University College London)

  • Stephan J L Bakker

    (University Medical Center Groningen, University of Groningen)

  • Diane M Becker

    (Johns Hopkins University School of Medicine)

  • Benjamin Lehne

    (Imperial College London)

  • David A Bennett

    (Rush University Medical Center
    Rush University Medical Center)

  • Leonard H Berg

    (University Medical Centre Utrecht, Utrecht University)

  • Sonja I Berndt

    (National Cancer Institute, National Institutes of Health)

  • Dwaipayan Bharadwaj

    (School of Biotechnology, Jawaharlal Nehru University)

  • Lawrence F Bielak

    (University of Michigan)

  • Murielle Bochud

    (University of Lausanne)

  • Mike Boehnke

    (University of Michigan)

  • Claude Bouchard

    (Pennington Biomedical Research Center)

  • Jonathan P Bradfield

    (Children’s Hospital of Philadelphia
    Quantinuum Research LLC)

  • Jennifer A Brody

    (University of Washington)

  • Archie Campbell

    (Institute of Genetics & Molecular Medicine, University of Edinburgh)

  • Shai Carmi

    (Hebrew University-Hadassah Medical Center)

  • Mark J Caulfield

    (Barts and The London School of Medicine and Dentistry, Queen Mary University of London
    William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London)

  • David Cesarini

    (New York University, New York
    Research Institute for Industrial Economics (IFN))

  • John C Chambers

    (Imperial College London
    Ealing Hospital, Middlesex
    Imperial College London
    Lee Kong Chian School of Medicine, Nanyang Technological University)

  • Giriraj Ratan Chandak

    (CSIR-Centre for Cellular and Molecular Biology)

  • Ching-Yu Cheng

    (Singapore Eye Research Institute, Singapore National Eye Centre, Singapore
    Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore
    Yong Loo Lin School of Medicine, National University of Singapore, Singapore)

  • Marina Ciullo

    (Institute of Genetics and Biophysics A. Buzzati-Traverso - CNR
    IRCCS Neuromed)

  • Marilyn Cornelis

    (Northwestern University Feinberg School of Medicine)

  • Daniele Cusi

    (University of Milano
    Institute of Biomedical Technologies Milano, National Research Council of Italy (CNR)
    Bio4Dreams Scientific Unit, Bio4Dreams SRL, Bio4Dreams - business nursery for life sciences)

  • George Davey Smith

    (MRC Integrative Epidemiology Unit at the University of Bristol
    Bristol Medical School)

  • Ian J Deary

    (University of Edinburgh
    University of Edinburgh)

  • Rajkumar Dorajoo

    (Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore)

  • Cornelia M Duijn

    (University of Oxford
    Erasmus University Medical Center)

  • David Ellinghaus

    (Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel)

  • Jeanette Erdmann

    (Institute for Cardiogenetics, University of Lübeck)

  • Johan G Eriksson

    (University of Helsinki
    National Institute for Health and Welfare
    Helsinki University Central Hospital
    Folkhälsan Research Centre)

  • Evangelos Evangelou

    (Imperial College London
    University of Ioannina Medical School)

  • Michele K Evans

    (National Institute on Aging, National Institutes of Health)

  • Jessica D Faul

    (Institute for Social Research, University of Michigan)

  • Bjarke Feenstra

    (Statens Serum Institut)

  • Mary Feitosa

    (Washington University School of Medicine)

  • Sylvain Foisy

    (Montreal Heart Institute)

  • Andre Franke

    (Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel)

  • Yechiel Friedlander

    (Hebrew University-Hadassah Medical Center)

  • Paolo Gasparini

    (University of Trieste
    Institute for Maternal and Child Health - IRCCS Burlo Garofolo)

  • Christian Gieger

    (Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health
    German Center for Diabetes Research (DZD))

  • Clicerio Gonzalez

    (Centro de Estudios en Diabetes, Unidad de Investigacion en Diabetes y Riesgo Cardiovascular, Centro de Investigacion en Salud Poblacional, Instituto Nacional de Salud Publica)

  • Philippe Goyette

    (Montreal Heart Institute)

  • Struan F A Grant

    (University of Pennsylvania
    Children’s Hospital of Philadelphia
    Perelman School of Medicine, University of Pennsylvania)

  • Lyn R Griffiths

    (Institute of Health and Biomedical Innovation, Queensland University of Technology)

  • Leif Groop

    (Finnish Institute for Molecular Medicine, University of Helsinki
    Lund University Diabetes Centre, Lund University, Skåne University Hospital)

  • Vilmundur Gudnason

    (Icelandic Heart Association
    University of Iceland)

  • Ulf Gyllensten

    (Uppsala University)

  • Hakon Hakonarson

    (Children’s Hospital of Philadelphia
    Perelman School of Medicine, University of Pennsylvania)

  • Anders Hamsten

    (Centre for Molecular Medicine)

  • Pim Harst

    (University of Groningen, University Medical Center Groningen, Department of Cardiology, Ther Netherlands)

  • Chew-Kiat Heng

    (Yong Loo Lin School of Medicine, National University of Singapore
    Khoo Teck Puat - National University Children’s Medical Institute, National University Health System)

  • Andrew A Hicks

    (Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck)

  • Hagit Hochner

    (Hebrew University-Hadassah Medical Center)

  • Heikki Huikuri

    (Research Unit of Internal Medicine, Medical Research Center Oulu, University of Oulu and Oulu University Hospital)

  • Steven C Hunt

    (Weill Cornell Medicine Qatar
    University of Utah School of Medicine)

  • Vincent W V Jaddoe

    (Erasmus University Medical Center
    The Generation R Study Group, Erasmus University Medical Center
    Erasmus University Medical Center)

  • Philip L Jager

    (Columbia University Medical Center
    Cell Circuits Program, Broad Institute)

  • Magnus Johannesson

    (Stockholm School of Economics)

  • Åsa Johansson

    (Uppsala University)

  • Jost B Jonas

    (Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Science Key Lab
    Medical Faculty Mannheim of the Ruprecht-Karls-University of Heidelberg)

  • J Wouter Jukema

    (Leiden University Medical Center)

  • Juhani Junttila

    (Research Unit of Internal Medicine, Medical Research Center Oulu, University of Oulu and Oulu University Hospital)

  • Jaakko Kaprio

    (Finnish Institute for Molecular Medicine, University of Helsinki
    University of Helsinki)

  • Sharon L. R. Kardia

    (University of Michigan)

  • Fredrik Karpe

    (University of Oxford, Headington
    Oxford NIHR Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital)

  • Meena Kumari

    (Institute for Social and Economic Research, University of Essex)

  • Markku Laakso

    (Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland
    Kuopio University Hospital)

  • Sander W Laan

    (University Medical Center Utrecht, University of Utrecht)

  • Jari Lahti

    (University of Helsinki, University of Helsinki
    University of Helsinki, University of Helsinki)

  • Matthias Laudes

    (University Hospital Schleswig-Holstein (UKSH))

  • Rodney A Lea

    (Institute of Health and Biomedical Innovation, Queensland University of Technology)

  • Wolfgang Lieb

    (Institute of Epidemiology and PopGen Biobank, University of Kiel)

  • Thomas Lumley

    (University of Auckland)

  • Nicholas G Martin

    (QIMR Berghofer Institute of Medical Research)

  • Winfried März

    (Heidelberg University
    Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz
    Synlab Academy, Synlab Holding Deutschland GmbH)

  • Giuseppe Matullo

    (University of Turin, Italy)

  • Mark I McCarthy

    (University of Oxford
    University of Oxford, Headington
    Oxford NIHR Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital)

  • Sarah E Medland

    (QIMR Berghofer Institute of Medical Research)

  • Tony R Merriman

    (University of Otago)

  • Andres Metspalu

    (University of Tartu, University of Tartu)

  • Brian F Meyer

    (King Faisal Specialist Hospital and Research Centre)

  • Karen L Mohlke

    (University of North Carolina)

  • Grant W Montgomery

    (QIMR Berghofer Institute of Medical Research
    Institute for Molecular Bioscience, The University of Queensland)

  • Dennis Mook-Kanamori

    (Leiden University Medical Center
    Leiden University Medical Center)

  • Patricia B Munroe

    (Barts and The London School of Medicine and Dentistry, Queen Mary University of London
    William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London)

  • Kari E North

    (University of North Carolina)

  • Dale R Nyholt

    (QIMR Berghofer Institute of Medical Research
    School of Biomedical Sciences, Institute of Health and Biomedical Innovation, Queensland University of Technology)

  • Jeffery R O’connell

    (University of Maryland, School of Medicine
    University of Maryland, School of Medicine)

  • Carole Ober

    (University of Chicago)

  • Albertine J Oldehinkel

    (Interdisciplinary Center Psychopathology and Emotion Regulation, University of Groningen, University Medical Center Groningen)

  • Walter Palmas

    (Columbia University Medical Center)

  • Colin Palmer

    (Pat Macpherson Centre for Pharmacogenetics and Pharmacogenomics, The School of Medicine, University of Dundee)

  • Gerard G Pasterkamp

    (University Medical Center Utrecht, University of Utrecht, Utrecht)

  • Etienne Patin

    (Human Evolutionary Genetics Unit, Institut Pasteur
    Centre National de la Recherche Scientifique (CNRS) UMR2000
    Institut Pasteur)

  • Craig E Pennell

    (School of Medicine and Public Health, Faculty of Medicine and Health, The University of Newcastle
    The University of Western Australia)

  • Louis Perusse

    (Laval University
    Institute of Nutrition and Functional Foods, Laval University)

  • Patricia A Peyser

    (University of Michigan)

  • Mario Pirastu

    (Institute of Genetic and Biomedical Research - Support Unity, National Research Council of Italy)

  • Tinca J. C. Polderman

    (Vrije Universiteit Amsterdam)

  • David J Porteous

    (University of Edinburgh
    Institute of Genetics & Molecular Medicine, University of Edinburgh)

  • Danielle Posthuma

    (Vrije Universiteit Amsterdam
    Amsterdam Neuroscience, VU Medical Centre)

  • Bruce M Psaty

    (University of Washington
    Kaiser Permanente Washington Health Research Institute)

  • John D Rioux

    (Montreal Heart Institute
    Université de Montréal)

  • Fernando Rivadeneira

    (Erasmus University Medical Center
    Erasmus University Medical Center
    The Generation R Study Group, Erasmus University Medical Center)

  • Charles Rotimi

    (National Human Genome Research Institute, National Institutes of Health)

  • Jerome I Rotter

    (LABioMed at Harbor-UCLA Medical Center, Torrance)

  • Igor Rudan

    (University of Edinburgh)

  • Hester M Ruijter

    (University Medical Center Utrecht, University of Utrecht, Utrecht)

  • Dharambir K Sanghera

    (University of Oklahoma Health Sciences Center
    Oklahoma Center for Neuroscience)

  • Naveed Sattar

    (Institute of Cardiovascular and Medical Sciences, University of Glasgow)

  • Reinhold Schmidt

    (Medical University of Graz)

  • Matthias B Schulze

    (German Institute of Human Nutrition Potsdam-Rehbruecke
    German Center for Diabetes Research (DZD)
    Institute of Nutritional Sciences, University of Potsdam)

  • Heribert Schunkert

    (Klinik für Herz- und Kreislauferkrankungen, Technische Universität München
    Deutsches Zentrum für Herz- und Kreislauferkrankungen (DZHK), Munich Heart Alliance)

  • Robert A Scott

    (University of Cambridge School of Clinical Medicine)

  • Alan R Shuldiner

    (University of Maryland, School of Medicine
    University of Maryland, School of Medicine
    Regeneron Pharmaceuticals, Inc)

  • Xueling Sim

    (National University of Singapore, Singapore)

  • Neil Small

    (University of Bradford)

  • Jennifer A Smith

    (University of Michigan
    Institute for Social Research, University of Michigan)

  • Nona Sotoodehnia

    (University of Washington)

  • E-Shyong Tai

    (National University of Singapore, Singapore
    Yong Loo Lin School of Medicine, National University of Singapore
    Duke-NUS Medical School, National University of Singapore, Singapore)

  • Alexander Teumer

    (partner site Greifswald
    Institute for Community Medicine, University Medicine Greifswald)

  • Nicholas J Timpson

    (MRC Integrative Epidemiology Unit at the University of Bristol
    Bristol Medical School, University of Bristol
    Avon Longitudinal Study of Parents and Children (ALSPAC), University of Bristol)

  • Daniela Toniolo

    (San Raffaele Research Institute)

  • David-Alexandre Tregouet

    (Sorbonne Universités)

  • Tiinamaija Tuomi

    (University of Helsinki
    University of Helsinki, Helsinki University Hospital
    Folkhalsan Research Center
    Research Program of Diabetes and Endocrinology, University of Helsinki)

  • Peter Vollenweider

    (Lausanne University Hospital)

  • Carol A Wang

    (School of Medicine and Public Health, Faculty of Medicine and Health, The University of Newcastle
    The University of Western Australia)

  • David R Weir

    (Institute for Social Research, University of Michigan)

  • John B Whitfield

    (QIMR Berghofer Institute of Medical Research)

  • Cisca Wijmenga

    (University Medical Centre Groningen, University of Groningen, Groningen, the Netherlands, Groningen)

  • Tien-Yin Wong

    (Singapore Eye Research Institute, Singapore National Eye Centre, Singapore
    Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore)

  • John Wright

    (Bradford Teaching Hospitals NHS Trust)

  • Jingyun Yang

    (Rush University Medical Center
    Rush University Medical Center)

  • Lei Yu

    (Rush University Medical Center
    Rush University Medical Center)

  • Babette S Zemel

    (Perelman School of Medicine, University of Pennsylvania
    Children’s Hospital of Philadelphia)

  • Alan B Zonderman

    (National Institute on Aging, National Institutes of Health)

  • Markus Perola

    (National Institute for Health and Welfare)

  • Patrik K. E. Magnusson

    (Karolinska Institutet)

  • André G Uitterlinden

    (Erasmus University Medical Center
    Erasmus University Medical Center
    The Generation R Study Group, Erasmus University Medical Center)

  • Jaspal S Kooner

    (Ealing Hospital, Middlesex
    Imperial College London
    Imperial College Healthcare NHS Trust, London
    National Heart and Lung Institute, Imperial College London)

  • Daniel I Chasman

    (Brigham and Women’s Hospital
    Harvard Medical School)

  • Ruth J. F. Loos

    (Ichan School of Medicine at Mount Sinai
    The Icahn School of Medicine at Mount Sinai)

  • Nora Franceschini

    (University of North Carolina)

  • Lude Franke

    (University Medical Centre Groningen, University of Groningen, Groningen, the Netherlands, Groningen)

  • Chris S Haley

    (Institute of Genetics and Molecular Medicine, University of Edinburgh
    Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush)

  • Caroline Hayward

    (Institute of Genetics and Molecular Medicine, University of Edinburgh)

  • Robin G Walters

    (University of Oxford)

  • John R. B. Perry

    (University of Cambridge School of Clinical Medicine)

  • Tōnu Esko

    (University of Tartu, University of Tartu
    Broad Institute, Broad Institute)

  • Agnar Helgason

    (deCODE genetics/Amgen Inc.
    University of Iceland)

  • Kari Stefansson

    (deCODE genetics/Amgen Inc.
    University of Iceland)

  • Peter K Joshi

    (University of Edinburgh)

  • Michiaki Kubo

    (RIKEN Center for Integrative Medical Sciences)

  • James F Wilson

    (University of Edinburgh
    Institute of Genetics and Molecular Medicine, University of Edinburgh)

Abstract

In many species, the offspring of related parents suffer reduced reproductive success, a phenomenon known as inbreeding depression. In humans, the importance of this effect has remained unclear, partly because reproduction between close relatives is both rare and frequently associated with confounding social factors. Here, using genomic inbreeding coefficients (FROH) for >1.4 million individuals, we show that FROH is significantly associated (p

Suggested Citation

  • David W Clark & Yukinori Okada & Kristjan H S Moore & Dan Mason & Nicola Pirastu & Ilaria Gandin & Hannele Mattsson & Catriona L K Barnes & Kuang Lin & Jing Hua Zhao & Patrick Deelen & Rebecca Rohde &, 2019. "Associations of autozygosity with a broad range of human phenotypes," Nature Communications, Nature, vol. 10(1), pages 1-17, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-12283-6
    DOI: 10.1038/s41467-019-12283-6
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    Cited by:

    1. Cotter, Daniel J. & Severson, Alissa L. & Carmi, Shai & Rosenberg, Noah A., 2022. "Limiting distribution of X-chromosomal coalescence times under first-cousin consanguineous mating," Theoretical Population Biology, Elsevier, vol. 147(C), pages 1-15.
    2. Elena Arciero & Sufyan A. Dogra & Daniel S. Malawsky & Massimo Mezzavilla & Theofanis Tsismentzoglou & Qin Qin Huang & Karen A. Hunt & Dan Mason & Saghira Malik Sharif & David A. Heel & Eamonn Sherida, 2021. "Fine-scale population structure and demographic history of British Pakistanis," Nature Communications, Nature, vol. 12(1), pages 1-16, December.
    3. Arianna Dalzero & Bret A. Beheim & Hillard Kaplan & Jonathan Stieglitz & Paul L. Hooper & Cody T. Ross & Michael Gurven & Dieter Lukas, 2024. "Cross-cousin marriage among Tsimane forager–horticulturalists during demographic transition and market integration," Post-Print hal-04524409, HAL.

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