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A multiscale signalling network map of innate immune response in cancer reveals cell heterogeneity signatures

Author

Listed:
  • Maria Kondratova

    (Mines Paris Tech)

  • Urszula Czerwinska

    (Mines Paris Tech
    Centre de Recherches Interdisciplinaires)

  • Nicolas Sompairac

    (Mines Paris Tech
    Centre de Recherches Interdisciplinaires)

  • Sebastian D. Amigorena

    (PSL Research University)

  • Vassili Soumelis

    (PSL Research University)

  • Emmanuel Barillot

    (Mines Paris Tech)

  • Andrei Zinovyev

    (Mines Paris Tech)

  • Inna Kuperstein

    (Mines Paris Tech)

Abstract

The lack of integrated resources depicting the complexity of the innate immune response in cancer represents a bottleneck for high-throughput data interpretation. To address this challenge, we perform a systematic manual literature mining of molecular mechanisms governing the innate immune response in cancer and represent it as a signalling network map. The cell-type specific signalling maps of macrophages, dendritic cells, myeloid-derived suppressor cells and natural killers are constructed and integrated into a comprehensive meta map of the innate immune response in cancer. The meta-map contains 1466 chemical species as nodes connected by 1084 biochemical reactions, and it is supported by information from 820 articles. The resource helps to interpret single cell RNA-Seq data from macrophages and natural killer cells in metastatic melanoma that reveal different anti- or pro-tumor sub-populations within each cell type. Here, we report a new open source analytic platform that supports data visualisation and interpretation of tumour microenvironment activity in cancer.

Suggested Citation

  • Maria Kondratova & Urszula Czerwinska & Nicolas Sompairac & Sebastian D. Amigorena & Vassili Soumelis & Emmanuel Barillot & Andrei Zinovyev & Inna Kuperstein, 2019. "A multiscale signalling network map of innate immune response in cancer reveals cell heterogeneity signatures," Nature Communications, Nature, vol. 10(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-12270-x
    DOI: 10.1038/s41467-019-12270-x
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