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Disposable ultrasound-sensing chronic cranial window by soft nanoimprinting lithography

Author

Listed:
  • Hao Li

    (Northwestern University)

  • Biqin Dong

    (Northwestern University
    Northwestern University)

  • Xian Zhang

    (Northwestern University
    HuaZhong University of Science and Technology)

  • Xiao Shu

    (Northwestern University)

  • Xiangfan Chen

    (Northwestern University)

  • Rihan Hai

    (Northwestern University)

  • David A. Czaplewski

    (Argonne National Laboratory)

  • Hao F. Zhang

    (Northwestern University)

  • Cheng Sun

    (Northwestern University)

Abstract

Chronic cranial window (CCW) is an essential tool in enabling longitudinal imaging and manipulation of various brain activities in live animals. However, an active CCW capable of sensing the concealed in vivo environment while simultaneously providing longitudinal optical access to the brain is not currently available. Here we report a disposable ultrasound-sensing CCW (usCCW) featuring an integrated transparent nanophotonic ultrasonic detector fabricated using soft nanoimprint lithography process. We optimize the sensor design and the associated fabrication process to significantly improve detection sensitivity and reliability, which are critical for the intend longitudinal in vivo investigations. Surgically implanting the usCCW on the skull creates a self-contained environment, maintaining optical access while eliminating the need for external ultrasound coupling medium for photoacoustic imaging. Using this usCCW, we demonstrate photoacoustic microscopy of cortical vascular network in live mice over 28 days. This work establishes the foundation for integrating photoacoustic imaging with modern brain research.

Suggested Citation

  • Hao Li & Biqin Dong & Xian Zhang & Xiao Shu & Xiangfan Chen & Rihan Hai & David A. Czaplewski & Hao F. Zhang & Cheng Sun, 2019. "Disposable ultrasound-sensing chronic cranial window by soft nanoimprinting lithography," Nature Communications, Nature, vol. 10(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-12178-6
    DOI: 10.1038/s41467-019-12178-6
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    Cited by:

    1. Jingshun Pan & Qiang Li & Yaoming Feng & Ruifeng Zhong & Zhihao Fu & Shuixian Yang & Weiyuan Sun & Bin Zhang & Qi Sui & Jun Chen & Yuecheng Shen & Zhaohui Li, 2023. "Parallel interrogation of the chalcogenide-based micro-ring sensor array for photoacoustic tomography," Nature Communications, Nature, vol. 14(1), pages 1-12, December.

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