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A potent broadly neutralizing human RSV antibody targets conserved site IV of the fusion glycoprotein

Author

Listed:
  • Aimin Tang

    (Merck & Co., Inc)

  • Zhifeng Chen

    (Merck & Co., Inc)

  • Kara S. Cox

    (Merck & Co., Inc)

  • Hua-Poo Su

    (Merck & Co., Inc)

  • Cheryl Callahan

    (Merck & Co., Inc)

  • Arthur Fridman

    (Merck & Co., Inc.)

  • Lan Zhang

    (Merck & Co., Inc)

  • Sangita B. Patel

    (Merck & Co., Inc)

  • Pedro J. Cejas

    (Merck & Co., Inc)

  • Ryan Swoyer

    (Merck & Co., Inc)

  • Sinoeun Touch

    (Merck & Co., Inc)

  • Michael P. Citron

    (Merck & Co., Inc)

  • Dhanasekaran Govindarajan

    (Merck & Co., Inc
    Janssen Research & Development)

  • Bin Luo

    (Merck & Co., Inc.)

  • Michael Eddins

    (Merck & Co., Inc)

  • John C. Reid

    (Merck & Co., Inc)

  • Stephen M. Soisson

    (Merck & Co., Inc)

  • Jennifer Galli

    (Merck & Co., Inc)

  • Dai Wang

    (Merck & Co., Inc)

  • Zhiyun Wen

    (Merck & Co., Inc)

  • Gwendolyn J. Heidecker

    (Merck & Co., Inc)

  • Danilo R. Casimiro

    (Merck & Co., Inc
    Sanofi Pasteur)

  • Daniel J. DiStefano

    (Merck & Co., Inc)

  • Kalpit A. Vora

    (Merck & Co., Inc)

Abstract

Respiratory syncytial virus (RSV) infection is the leading cause of hospitalization and infant mortality under six months of age worldwide; therefore, the prevention of RSV infection in all infants represents a significant unmet medical need. Here we report the isolation of a potent and broadly neutralizing RSV monoclonal antibody derived from a human memory B-cell. This antibody, RB1, is equipotent on RSV A and B subtypes, potently neutralizes a diverse panel of clinical isolates in vitro and demonstrates in vivo protection. It binds to a highly conserved epitope in antigenic site IV of the RSV fusion glycoprotein. RB1 is the parental antibody to MK-1654 which is currently in clinical development for the prevention of RSV infection in infants.

Suggested Citation

  • Aimin Tang & Zhifeng Chen & Kara S. Cox & Hua-Poo Su & Cheryl Callahan & Arthur Fridman & Lan Zhang & Sangita B. Patel & Pedro J. Cejas & Ryan Swoyer & Sinoeun Touch & Michael P. Citron & Dhanasekaran, 2019. "A potent broadly neutralizing human RSV antibody targets conserved site IV of the fusion glycoprotein," Nature Communications, Nature, vol. 10(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-12137-1
    DOI: 10.1038/s41467-019-12137-1
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    Cited by:

    1. Madelyn Cabán & Justas V. Rodarte & Madeleine Bibby & Matthew D. Gray & Justin J. Taylor & Marie Pancera & Jim Boonyaratanakornkit, 2023. "Cross-protective antibodies against common endemic respiratory viruses," Nature Communications, Nature, vol. 14(1), pages 1-15, December.

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