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Single- and multi-component chiral supraparticles as modular enantioselective catalysts

Author

Listed:
  • Si Li

    (Jiangnan University
    University of Michigan
    University of Michigan)

  • Juan Liu

    (University of Colorado Boulder, Boulder)

  • Naomi S. Ramesar

    (University of Michigan
    University of Michigan)

  • Hendrik Heinz

    (University of Colorado Boulder, Boulder)

  • Liguang Xu

    (Jiangnan University)

  • Chuanlai Xu

    (Jiangnan University)

  • Nicholas A. Kotov

    (University of Michigan
    University of Michigan
    University of Michigan
    University of Michigan)

Abstract

Nanoscale biological assemblies exemplified by exosomes, endosomes and capsids, play crucial roles in all living systems. Supraparticles (SP) from inorganic nanoparticles (NPs) replicate structural characteristics of these bioassemblies, but it is unknown whether they can mimic their biochemical functions. Here, we show that chiral ZnS NPs self-assemble into 70–100 nm SPs that display sub-nanoscale porosity associated with interstitial spaces between constituent NPs. Similarly to photosynthetic bacterial organelles, these SPs can serve as photocatalysts, enantioselectively converting L- or D-tyrosine (Tyr) into dityrosine (diTyr). Experimental data and molecular dynamic simulations indicate that the chiral bias of the photocatalytic reaction is associated with the chiral environment of interstitial spaces and preferential partitioning of enantiomers into SPs, which can be further enhanced by co-assembling ZnS with Au NPs. Besides replicating a specific function of biological nanoassemblies, these findings establish a path to enantioselective oxidative coupling of phenols for biomedical and other needs.

Suggested Citation

  • Si Li & Juan Liu & Naomi S. Ramesar & Hendrik Heinz & Liguang Xu & Chuanlai Xu & Nicholas A. Kotov, 2019. "Single- and multi-component chiral supraparticles as modular enantioselective catalysts," Nature Communications, Nature, vol. 10(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-12134-4
    DOI: 10.1038/s41467-019-12134-4
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