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A hybrid sub-lineage of Listeria monocytogenes comprising hypervirulent isolates

Author

Listed:
  • Yuelan Yin

    (Yangzhou University
    Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Disease and Zoonoses)

  • Hao Yao

    (Yangzhou University
    Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Disease and Zoonoses)

  • Swapnil Doijad

    (Justus-Liebig University
    Campus Gießen, Justus-Liebig University)

  • Suwei Kong

    (Yangzhou University)

  • Yang Shen

    (ETH Zurich)

  • Xuexue Cai

    (Yangzhou University)

  • Weijun Tan

    (Yangzhou University)

  • Yuting Wang

    (Yangzhou University)

  • Youwei Feng

    (Yangzhou University)

  • Zhiting Ling

    (Yangzhou University)

  • Guoliang Wang

    (Yangzhou University
    Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Disease and Zoonoses)

  • Yachen Hu

    (Yangzhou University
    Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Disease and Zoonoses)

  • Kai Lian

    (Yangzhou University)

  • Xinyu Sun

    (Yangzhou University)

  • Yuliang Liu

    (China Animal Disease Control Center)

  • Chuanbin Wang

    (China Animal Disease Control Center)

  • Kuhua Jiao

    (Yangzhou University
    Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Disease and Zoonoses)

  • Guoping Liu

    (Xuyi Center for Animal Disease Control and Prevention)

  • Ruilong Song

    (Yangzhou University
    Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Disease and Zoonoses)

  • Xiang Chen

    (Yangzhou University
    Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Disease and Zoonoses)

  • Zhiming Pan

    (Yangzhou University
    Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Disease and Zoonoses)

  • Martin J. Loessner

    (ETH Zurich)

  • Trinad Chakraborty

    (Yangzhou University
    Justus-Liebig University
    Campus Gießen, Justus-Liebig University)

  • Xin’an Jiao

    (Yangzhou University
    Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Disease and Zoonoses)

Abstract

The foodborne pathogen Listeria monocytogenes (Lm) is a highly heterogeneous species and currently comprises of 4 evolutionarily distinct lineages. Here, we characterize isolates from severe ovine listeriosis outbreaks that represent a hybrid sub-lineage of the major lineage II (HSL-II) and serotype 4h. HSL-II isolates are highly virulent and exhibit higher organ colonization capacities than well-characterized hypervirulent strains of Lm in an orogastric mouse infection model. The isolates harbour both the Lm Pathogenicity Island (LIPI)-1 and a truncated LIPI-2 locus, encoding sphingomyelinase (SmcL), a virulence factor required for invasion and bacterial translocation from the gut, and other non-contiguous chromosomal segments from another pathogenic species, L. ivanovii. HSL-II isolates exhibit a unique wall teichoic acid (WTA) structure essential for resistance to antimicrobial peptides, bacterial invasion and virulence. The discovery of isolates harbouring pan-species virulence genes of the genus Listeria warrants global efforts to identify further hypervirulent lineages of Lm.

Suggested Citation

  • Yuelan Yin & Hao Yao & Swapnil Doijad & Suwei Kong & Yang Shen & Xuexue Cai & Weijun Tan & Yuting Wang & Youwei Feng & Zhiting Ling & Guoliang Wang & Yachen Hu & Kai Lian & Xinyu Sun & Yuliang Liu & C, 2019. "A hybrid sub-lineage of Listeria monocytogenes comprising hypervirulent isolates," Nature Communications, Nature, vol. 10(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-12072-1
    DOI: 10.1038/s41467-019-12072-1
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    Cited by:

    1. Corina N. D’Alessandro-Gabazza & Taro Yasuma & Tetsu Kobayashi & Masaaki Toda & Ahmed M. Abdel-Hamid & Hajime Fujimoto & Osamu Hataji & Hiroki Nakahara & Atsuro Takeshita & Kota Nishihama & Tomohito O, 2022. "Inhibition of lung microbiota-derived proapoptotic peptides ameliorates acute exacerbation of pulmonary fibrosis," Nature Communications, Nature, vol. 13(1), pages 1-23, December.

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