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Bridging of Neisseria gonorrhoeae lineages across sexual networks in the HIV pre-exposure prophylaxis era

Author

Listed:
  • Deborah A. Williamson

    (The University of Melbourne at The Peter Doherty Institute for Infection and Immunity)

  • Eric P. F. Chow

    (Melbourne Sexual Health Centre, Alfred Health
    Monash University)

  • Claire L. Gorrie

    (The University of Melbourne at The Peter Doherty Institute for Infection and Immunity)

  • Torsten Seemann

    (The University of Melbourne at The Peter Doherty Institute for Infection and Immunity
    Melbourne Bioinformatics Group)

  • Danielle J. Ingle

    (The University of Melbourne at The Peter Doherty Institute for Infection and Immunity
    The Australian National University)

  • Nasra Higgins

    (Victorian Department of Health and Human Services)

  • Marion Easton

    (Victorian Department of Health and Human Services)

  • George Taiaroa

    (The University of Melbourne at The Peter Doherty Institute for Infection and Immunity)

  • Yonatan H. Grad

    (Harvard T. H. Chan School of Public Health)

  • Jason C. Kwong

    (The University of Melbourne at The Peter Doherty Institute for Infection and Immunity)

  • Christopher K. Fairley

    (Melbourne Sexual Health Centre, Alfred Health
    Monash University)

  • Marcus Y. Chen

    (Melbourne Sexual Health Centre, Alfred Health
    Monash University)

  • Benjamin P. Howden

    (The University of Melbourne at The Peter Doherty Institute for Infection and Immunity)

Abstract

Whole genome sequencing (WGS) has been used to investigate transmission of Neisseria gonorrhoeae, but to date, most studies have not combined genomic data with detailed information on sexual behaviour to define the extent of transmission across population risk groups (bridging). Here, through combined epidemiological and genomic analysis of 2,186N. gonorrhoeae isolates from Australia, we show widespread transmission of N. gonorrhoeae within and between population groups. We describe distinct transmission clusters associated with men who have sex with men (MSM) and heterosexuals, and men who have sex with men and women (MSMW) are identified as a possible bridging population between these groups. Further, the study identifies transmission of N. gonorrhoeae between HIV-positive and HIV-negative individuals receiving pre-exposure prophylaxis (PrEP). Our data highlight several groups that can be targeted for interventions aimed at improving gonorrhoea control, including returning travellers, sex workers, and PrEP users.

Suggested Citation

  • Deborah A. Williamson & Eric P. F. Chow & Claire L. Gorrie & Torsten Seemann & Danielle J. Ingle & Nasra Higgins & Marion Easton & George Taiaroa & Yonatan H. Grad & Jason C. Kwong & Christopher K. Fa, 2019. "Bridging of Neisseria gonorrhoeae lineages across sexual networks in the HIV pre-exposure prophylaxis era," Nature Communications, Nature, vol. 10(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-12053-4
    DOI: 10.1038/s41467-019-12053-4
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    Cited by:

    1. Mona L. Taouk & George Taiaroa & Sebastian Duchene & Soo Jen Low & Charlie K. Higgs & Darren Y. J. Lee & Shivani Pasricha & Nasra Higgins & Danielle J. Ingle & Benjamin P. Howden & Marcus Y. Chen & Ch, 2024. "Longitudinal genomic analysis of Neisseria gonorrhoeae transmission dynamics in Australia," Nature Communications, Nature, vol. 15(1), pages 1-12, December.

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