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PCP and Wnt pathway components act in parallel during zebrafish mechanosensory hair cell orientation

Author

Listed:
  • Joaquin Navajas Acedo

    (Stowers Institute for Medical Research)

  • Matthew G. Voas

    (Stowers Institute for Medical Research)

  • Richard Alexander

    (Stowers Institute for Medical Research)

  • Thomas Woolley

    (Cardiff University)

  • Jay R. Unruh

    (Stowers Institute for Medical Research)

  • Hua Li

    (Stowers Institute for Medical Research)

  • Cecilia Moens

    (Fred Hutchinson Cancer Research Center, Basic Sciences Division)

  • Tatjana Piotrowski

    (Stowers Institute for Medical Research)

Abstract

Planar cell polarity (PCP) plays crucial roles in developmental processes such as gastrulation, neural tube closure and hearing. Wnt pathway mutants are often classified as PCP mutants due to similarities between their phenotypes. Here, we show that in the zebrafish lateral line, disruptions of the PCP and Wnt pathways have differential effects on hair cell orientations. While mutations in the PCP genes vangl2 and scrib cause random orientations of hair cells, mutations in wnt11f1, gpc4 and fzd7a/b induce hair cells to adopt a concentric pattern. This concentric pattern is not caused by defects in PCP but is due to misaligned support cells. The molecular basis of the support cell defect is unknown but we demonstrate that the PCP and Wnt pathways work in parallel to establish proper hair cell orientation. Consequently, hair cell orientation defects are not solely explained by defects in PCP signaling, and some hair cell phenotypes warrant re-evaluation.

Suggested Citation

  • Joaquin Navajas Acedo & Matthew G. Voas & Richard Alexander & Thomas Woolley & Jay R. Unruh & Hua Li & Cecilia Moens & Tatjana Piotrowski, 2019. "PCP and Wnt pathway components act in parallel during zebrafish mechanosensory hair cell orientation," Nature Communications, Nature, vol. 10(1), pages 1-17, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-12005-y
    DOI: 10.1038/s41467-019-12005-y
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    Cited by:

    1. Zhou, Ping & Yao, Zhao & Ma, Jun & Zhu, Zhigang, 2021. "A piezoelectric sensing neuron and resonance synchronization between auditory neurons under stimulus," Chaos, Solitons & Fractals, Elsevier, vol. 145(C).

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