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Central nicotine induces browning through hypothalamic κ opioid receptor

Author

Listed:
  • Patricia Seoane-Collazo

    (University of Santiago de Compostela-Instituto de Investigación Sanitaria
    CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN))

  • Laura Liñares-Pose

    (University of Santiago de Compostela-Instituto de Investigación Sanitaria
    CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN))

  • Eva Rial-Pensado

    (University of Santiago de Compostela-Instituto de Investigación Sanitaria
    CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN))

  • Amparo Romero-Picó

    (University of Santiago de Compostela-Instituto de Investigación Sanitaria
    CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN))

  • José María Moreno-Navarrete

    (CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN)
    Institut D’investigació Biomèdica de Girona (IdIBGi) and University of Girona)

  • Noelia Martínez-Sánchez

    (University of Santiago de Compostela-Instituto de Investigación Sanitaria
    University of Oxford)

  • Pablo Garrido-Gil

    (CiMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria
    CIBER Enfermedades Neurodegenerativas (CIBERNED))

  • Ramón Iglesias-Rey

    (Instituto de Investigación Sanitaria)

  • Donald A. Morgan

    (University of Iowa)

  • Naoki Tomasini

    (Instituto Gulbenkian de Ciência)

  • Samuel Andrew Malone

    (University of Oxford)

  • Ana Senra

    (University of Santiago de Compostela-Instituto de Investigación Sanitaria
    CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN))

  • Cintia Folgueira

    (University of Santiago de Compostela-Instituto de Investigación Sanitaria
    CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN))

  • Gema Medina-Gomez

    (Universidad Rey Juan Carlos)

  • Tomás Sobrino

    (Instituto de Investigación Sanitaria)

  • José L. Labandeira-García

    (CiMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria
    CIBER Enfermedades Neurodegenerativas (CIBERNED))

  • Rubén Nogueiras

    (University of Santiago de Compostela-Instituto de Investigación Sanitaria
    CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN))

  • Ana I. Domingos

    (University of Oxford)

  • José-Manuel Fernández-Real

    (CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN)
    Institut D’investigació Biomèdica de Girona (IdIBGi) and University of Girona)

  • Kamal Rahmouni

    (University of Iowa
    University of Iowa)

  • Carlos Diéguez

    (University of Santiago de Compostela-Instituto de Investigación Sanitaria
    CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN))

  • Miguel López

    (University of Santiago de Compostela-Instituto de Investigación Sanitaria
    CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN))

Abstract

Increased body weight is a major factor that interferes with smoking cessation. Nicotine, the main bioactive compound in tobacco, has been demonstrated to have an impact on energy balance, since it affects both feeding and energy expenditure at the central level. Among the central actions of nicotine on body weight, much attention has been focused on its effect on brown adipose tissue (BAT) thermogenesis, though its effect on browning of white adipose tissue (WAT) is unclear. Here, we show that nicotine induces the browning of WAT through a central mechanism and that this effect is dependent on the κ opioid receptor (KOR), specifically in the lateral hypothalamic area (LHA). Consistent with these findings, smokers show higher levels of uncoupling protein 1 (UCP1) expression in WAT, which correlates with smoking status. These data demonstrate that central nicotine-induced modulation of WAT browning may be a target against human obesity.

Suggested Citation

  • Patricia Seoane-Collazo & Laura Liñares-Pose & Eva Rial-Pensado & Amparo Romero-Picó & José María Moreno-Navarrete & Noelia Martínez-Sánchez & Pablo Garrido-Gil & Ramón Iglesias-Rey & Donald A. Morgan, 2019. "Central nicotine induces browning through hypothalamic κ opioid receptor," Nature Communications, Nature, vol. 10(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-12004-z
    DOI: 10.1038/s41467-019-12004-z
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    Cited by:

    1. Antía González-Vila & María Luengo-Mateos & María Silveira-Loureiro & Pablo Garrido-Gil & Nataliia Ohinska & Marco González-Domínguez & Jose Luis Labandeira-García & Cristina García-Cáceres & Miguel L, 2023. "Astrocytic insulin receptor controls circadian behavior via dopamine signaling in a sexually dimorphic manner," Nature Communications, Nature, vol. 14(1), pages 1-21, December.

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