IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v10y2019i1d10.1038_s41467-019-11968-2.html
   My bibliography  Save this article

Gastroesophageal reflux GWAS identifies risk loci that also associate with subsequent severe esophageal diseases

Author

Listed:
  • Jiyuan An

    (Statistical Genetics, QIMR Berghofer Medical Research Institute)

  • Puya Gharahkhani

    (Statistical Genetics, QIMR Berghofer Medical Research Institute)

  • Matthew H. Law

    (Statistical Genetics, QIMR Berghofer Medical Research Institute)

  • Jue-Sheng Ong

    (Statistical Genetics, QIMR Berghofer Medical Research Institute)

  • Xikun Han

    (Statistical Genetics, QIMR Berghofer Medical Research Institute)

  • Catherine M. Olsen

    (Cancer Control, QIMR Berghofer Medical Research Institute)

  • Rachel E. Neale

    (Cancer Aetiology and Prevention, QIMR Berghofer Medical Research Institute
    The University of Queensland
    the Queensland University of Technology)

  • John Lai

    (The University of Melbourne)

  • Tom L. Vaughan

    (Division of Public Health Sciences, Fred Hutchinson Cancer Research Center)

  • Ines Gockel

    (Thoracic and Vascular Surgery, University Hospital of Leipzig)

  • René Thieme

    (Thoracic and Vascular Surgery, University Hospital of Leipzig)

  • Anne C. Böhmer

    (University of Bonn, School of Medicine & University Hospital Bonn
    University of Bonn)

  • Janusz Jankowski

    (Royal College of Surgeons in Ireland)

  • Rebecca C. Fitzgerald

    (Hutchison-MRC Research Centre and University of Cambridge)

  • Johannes Schumacher

    (University of Bonn, School of Medicine & University Hospital Bonn
    University of Bonn
    University Hospital of Marburg)

  • Claire Palles

    (University of Birmingham)

  • David C. Whiteman

    (Cancer Control, QIMR Berghofer Medical Research Institute)

  • Stuart MacGregor

    (Statistical Genetics, QIMR Berghofer Medical Research Institute)

Abstract

Gastroesophageal reflux disease (GERD) is caused by gastric acid entering the esophagus. GERD has high prevalence and is the major risk factor for Barrett’s esophagus (BE) and esophageal adenocarcinoma (EA). We conduct a large GERD GWAS meta-analysis (80,265 cases, 305,011 controls), identifying 25 independent genome-wide significant loci for GERD. Several of the implicated genes are existing or putative drug targets. Loci discovery is greatest with a broad GERD definition (including cases defined by self-report or medication data). Further, 91% of the GERD risk-increasing alleles also increase BE and/or EA risk, greatly expanding gene discovery for these traits. Our results map genes for GERD and related traits and uncover potential new drug targets for these conditions.

Suggested Citation

  • Jiyuan An & Puya Gharahkhani & Matthew H. Law & Jue-Sheng Ong & Xikun Han & Catherine M. Olsen & Rachel E. Neale & John Lai & Tom L. Vaughan & Ines Gockel & René Thieme & Anne C. Böhmer & Janusz Janko, 2019. "Gastroesophageal reflux GWAS identifies risk loci that also associate with subsequent severe esophageal diseases," Nature Communications, Nature, vol. 10(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-11968-2
    DOI: 10.1038/s41467-019-11968-2
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-019-11968-2
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-019-11968-2?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-11968-2. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.