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Assisted reproductive technologies are associated with limited epigenetic variation at birth that largely resolves by adulthood

Author

Listed:
  • Boris Novakovic

    (Murdoch Children’s Research Institute
    University of Melbourne)

  • Sharon Lewis

    (Murdoch Children’s Research Institute
    University of Melbourne)

  • Jane Halliday

    (Murdoch Children’s Research Institute
    University of Melbourne)

  • Joanne Kennedy

    (Murdoch Children’s Research Institute)

  • David P. Burgner

    (Murdoch Children’s Research Institute
    University of Melbourne
    Monash University
    The Royal Children’s Hospital)

  • Anna Czajko

    (Murdoch Children’s Research Institute)

  • Bowon Kim

    (Murdoch Children’s Research Institute)

  • Alexandra Sexton-Oates

    (Murdoch Children’s Research Institute)

  • Markus Juonala

    (Murdoch Children’s Research Institute
    University of Turku
    Division of Medicine Turku University Hospital)

  • Karin Hammarberg

    (Monash University
    Victorian Assisted Reproductive Treatment Authority)

  • David J. Amor

    (Murdoch Children’s Research Institute
    University of Melbourne
    The Royal Children’s Hospital)

  • Lex W. Doyle

    (Murdoch Children’s Research Institute
    University of Melbourne
    University of Melbourne
    The Royal Women’s Hospital)

  • Sarath Ranganathan

    (Murdoch Children’s Research Institute
    University of Melbourne
    The Royal Children’s Hospital)

  • Liam Welsh

    (Murdoch Children’s Research Institute
    The Royal Children’s Hospital)

  • Michael Cheung

    (Murdoch Children’s Research Institute
    University of Melbourne
    The Royal Children’s Hospital)

  • John McBain

    (Royal Women’s Hospital)

  • Robert McLachlan

    (Hudson Institute of Medical Research
    Monash IVF Group Pty Ltd
    Monash University)

  • Richard Saffery

    (Murdoch Children’s Research Institute
    University of Melbourne)

Abstract

More than 7 million individuals have been conceived by Assisted Reproductive Technologies (ART) and there is clear evidence that ART is associated with a range of adverse early life outcomes, including rare imprinting disorders. The periconception period and early embryogenesis are associated with widespread epigenetic remodeling, which can be influenced by ART, with effects on the developmental trajectory in utero, and potentially on health throughout life. Here we profile genome-wide DNA methylation in blood collected in the newborn period and in adulthood (age 22–35 years) from a unique longitudinal cohort of ART-conceived individuals, previously shown to have no differences in health outcomes in early adulthood compared with non-ART-conceived individuals. We show evidence for specific ART-associated variation in methylation around birth, most of which occurred independently of embryo culturing. Importantly, ART-associated epigenetic variation at birth largely resolves by adulthood with no direct evidence that it impacts on development and health.

Suggested Citation

  • Boris Novakovic & Sharon Lewis & Jane Halliday & Joanne Kennedy & David P. Burgner & Anna Czajko & Bowon Kim & Alexandra Sexton-Oates & Markus Juonala & Karin Hammarberg & David J. Amor & Lex W. Doyle, 2019. "Assisted reproductive technologies are associated with limited epigenetic variation at birth that largely resolves by adulthood," Nature Communications, Nature, vol. 10(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-11929-9
    DOI: 10.1038/s41467-019-11929-9
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