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NK cells are activated and primed for skin-homing during acute dengue virus infection in humans

Author

Listed:
  • Christine L. Zimmer

    (Karolinska University Hospital)

  • Martin Cornillet

    (Karolinska University Hospital)

  • Carles Solà-Riera

    (Karolinska University Hospital)

  • Ka-Wai Cheung

    (DUKE-NUS Medical School)

  • Martin A. Ivarsson

    (Karolinska University Hospital)

  • Mei Qiu Lim

    (DUKE-NUS Medical School)

  • Nicole Marquardt

    (Karolinska University Hospital)

  • Yee-Sin Leo

    (Tan Tock Seng Hospital
    National University of Singapore
    National University of Singapore
    Nanyang Technological University)

  • David Chien Lye

    (Tan Tock Seng Hospital
    National University of Singapore
    Nanyang Technological University)

  • Jonas Klingström

    (Karolinska University Hospital)

  • Paul A. MacAry

    (National University of Singapore)

  • Hans-Gustaf Ljunggren

    (Karolinska University Hospital)

  • Laura Rivino

    (DUKE-NUS Medical School
    University of Bristol)

  • Niklas K. Björkström

    (Karolinska University Hospital)

Abstract

Despite animal models showing that natural killer (NK) cells are important players in the early defense against many viral infections, the NK cell response is poorly understood in humans. Here we analyze the phenotype, temporal dynamics, regulation and trafficking of NK cells in a patient cohort with acute dengue virus infection. NK cells are robustly activated and proliferate during the first week after symptom debut. Increased IL-18 levels in plasma and in induced skin blisters of DENV-infected patients, as well as concomitant signaling downstream of the IL-18R, suggests an IL-18-dependent mechanism in driving the proliferative NK cell response. Responding NK cells have a less mature phenotype and a distinct chemokine-receptor imprint indicative of skin-homing. A corresponding NK cell subset can be localized to skin early during acute infection. These data provide evidence of an IL-18-driven NK cell proliferation and priming for skin-homing during an acute viral infection in humans.

Suggested Citation

  • Christine L. Zimmer & Martin Cornillet & Carles Solà-Riera & Ka-Wai Cheung & Martin A. Ivarsson & Mei Qiu Lim & Nicole Marquardt & Yee-Sin Leo & David Chien Lye & Jonas Klingström & Paul A. MacAry & H, 2019. "NK cells are activated and primed for skin-homing during acute dengue virus infection in humans," Nature Communications, Nature, vol. 10(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-11878-3
    DOI: 10.1038/s41467-019-11878-3
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    Cited by:

    1. Xiangjun Liu & Shanzhao Jin & Simeng Hu & Ruoyan Li & Haihao Pan & Yi Liu & Pan Lai & Deshu Xu & Jingru Sun & Ziyang Liu & Yumei Gao & Yifan Zhao & Fengjie Liu & Yu Xiao & Yingyi Li & Yujie Wen & Zhuo, 2022. "Single-cell transcriptomics links malignant T cells to the tumor immune landscape in cutaneous T cell lymphoma," Nature Communications, Nature, vol. 13(1), pages 1-18, December.

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