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An ancestral NB-LRR with duplicated 3′UTRs confers stripe rust resistance in wheat and barley

Author

Listed:
  • Chaozhong Zhang

    (Shandong Agricultural University
    University of Idaho)

  • Lin Huang

    (Sichuan Agricultural University)

  • Huifei Zhang

    (University of Idaho)

  • Qunqun Hao

    (University of Idaho)

  • Bo Lyu

    (University of Idaho)

  • Meinan Wang

    (Washington State University)

  • Lynn Epstein

    (University of California)

  • Miao Liu

    (Sichuan Agricultural University)

  • Chunlan Kou

    (Sichuan Agricultural University)

  • Juan Qi

    (Shandong Agricultural University)

  • Fengjuan Chen

    (Shandong Agricultural University)

  • Mengkai Li

    (Shandong Agricultural University)

  • Ge Gao

    (Shandong Agricultural University)

  • Fei Ni

    (Shandong Agricultural University)

  • Lianquan Zhang

    (Sichuan Agricultural University)

  • Ming Hao

    (Sichuan Agricultural University)

  • Jirui Wang

    (Sichuan Agricultural University)

  • Xianming Chen

    (Wheat Health, Genetics, and Quality Research Unit, USDA-ARS)

  • Ming-Cheng Luo

    (University of California)

  • Youliang Zheng

    (Sichuan Agricultural University)

  • Jiajie Wu

    (Shandong Agricultural University)

  • Dengcai Liu

    (Sichuan Agricultural University
    Sichuan Agricultural University)

  • Daolin Fu

    (University of Idaho)

Abstract

Wheat stripe rust, caused by Puccinia striiformis f. sp. tritici (Pst), is a global threat to wheat production. Aegilops tauschii, one of the wheat progenitors, carries the YrAS2388 locus for resistance to Pst on chromosome 4DS. We reveal that YrAS2388 encodes a typical nucleotide oligomerization domain-like receptor (NLR). The Pst-resistant allele YrAS2388R has duplicated 3’ untranslated regions and is characterized by alternative splicing in the nucleotide-binding domain. Mutation of the YrAS2388R allele disrupts its resistance to Pst in synthetic hexaploid wheat; transgenic plants with YrAS2388R show resistance to eleven Pst races in common wheat and one race of P. striiformis f. sp. hordei in barley. The YrAS2388R allele occurs only in Ae. tauschii and the Ae. tauschii-derived synthetic wheat; it is absent in 100% (n = 461) of common wheat lines tested. The cloning of YrAS2388R will facilitate breeding for stripe rust resistance in wheat and other Triticeae species.

Suggested Citation

  • Chaozhong Zhang & Lin Huang & Huifei Zhang & Qunqun Hao & Bo Lyu & Meinan Wang & Lynn Epstein & Miao Liu & Chunlan Kou & Juan Qi & Fengjuan Chen & Mengkai Li & Ge Gao & Fei Ni & Lianquan Zhang & Ming , 2019. "An ancestral NB-LRR with duplicated 3′UTRs confers stripe rust resistance in wheat and barley," Nature Communications, Nature, vol. 10(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-11872-9
    DOI: 10.1038/s41467-019-11872-9
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