IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v10y2019i1d10.1038_s41467-019-11862-x.html
   My bibliography  Save this article

The molecular origin and taxonomy of mucinous ovarian carcinoma

Author

Listed:
  • Dane Cheasley

    (Peter MacCallum Cancer Centre)

  • Matthew J. Wakefield

    (Walter and Eliza Hall Institute
    The University of Melbourne)

  • Georgina L. Ryland

    (Peter MacCallum Cancer Centre)

  • Prue E. Allan

    (Peter MacCallum Cancer Centre)

  • Kathryn Alsop

    (Peter MacCallum Cancer Centre
    The University of Melbourne)

  • Kaushalya C. Amarasinghe

    (Peter MacCallum Cancer Centre)

  • Sumitra Ananda

    (Peter MacCallum Cancer Centre
    Western Health)

  • Michael S. Anglesio

    (University of British Columbia)

  • George Au-Yeung

    (Peter MacCallum Cancer Centre
    The University of Melbourne)

  • Maret Böhm

    (Kinghorn Cancer Centre and Garvan Institute of Medical Research)

  • David D. L. Bowtell

    (Peter MacCallum Cancer Centre
    The University of Melbourne)

  • Alison Brand

    (University of Sydney)

  • Georgia Chenevix-Trench

    (Queensland Institute of Medical Research)

  • Michael Christie

    (The University of Melbourne
    Royal Melbourne Hospital)

  • Yoke-Eng Chiew

    (University of Sydney)

  • Michael Churchman

    (University of Edinburgh)

  • Anna DeFazio

    (University of Sydney)

  • Renee Demeo

    (Peter MacCallum Cancer Centre)

  • Rhiannon Dudley

    (Hudson Institute of Medical Research)

  • Nicole Fairweather

    (Hudson Institute of Medical Research)

  • Clare G. Fedele

    (Peter MacCallum Cancer Centre
    The University of Melbourne)

  • Sian Fereday

    (Peter MacCallum Cancer Centre
    The University of Melbourne)

  • Stephen B. Fox

    (Peter MacCallum Cancer Centre
    The University of Melbourne)

  • C Blake Gilks

    (University of British Columbia)

  • Charlie Gourley

    (University of Edinburgh)

  • Neville F. Hacker

    (The University of New South Wales)

  • Alison M. Hadley

    (Royal Brisbane and Womens Hospital)

  • Joy Hendley

    (Peter MacCallum Cancer Centre)

  • Gwo-Yaw Ho

    (Walter and Eliza Hall Institute)

  • Siobhan Hughes

    (Peter MacCallum Cancer Centre)

  • David G. Hunstman

    (University of British Columbia)

  • Sally M. Hunter

    (Peter MacCallum Cancer Centre)

  • Tom W. Jobling

    (Monash Medical Centre)

  • Kimberly R. Kalli

    (Mayo Clinic)

  • Scott H. Kaufmann

    (Mayo Clinic)

  • Catherine J. Kennedy

    (University of Sydney)

  • Martin Köbel

    (The University of Calgary)

  • Cecile Page

    (CRCHUM)

  • Jason Li

    (Peter MacCallum Cancer Centre)

  • Richard Lupat

    (Peter MacCallum Cancer Centre)

  • Orla M. McNally

    (The University of Melbourne
    Royal Womens Hospital)

  • Jessica N. McAlpine

    (University of British Columbia)

  • Anne-Marie Mes-Masson

    (CRCHUM
    University of Montreal)

  • Linda Mileshkin

    (Peter MacCallum Cancer Centre)

  • Diane M. Provencher

    (CRCHUM
    Centre Hospitalier de L’Université de Montreal)

  • Jan Pyman

    (Royal Womens Hospital
    Royal Children’s Hospital)

  • Kurosh Rahimi

    (CRCHUM
    Centre Hospitalier de L’Université de Montreal)

  • Simone M. Rowley

    (Peter MacCallum Cancer Centre)

  • Carolina Salazar

    (Peter MacCallum Cancer Centre)

  • Goli Samimi

    (Kinghorn Cancer Centre and Garvan Institute of Medical Research)

  • Hugo Saunders

    (Peter MacCallum Cancer Centre)

  • Timothy Semple

    (Peter MacCallum Cancer Centre)

  • Ragwha Sharma

    (University of Sydney
    NSW Health Pathology)

  • Alice J. Sharpe

    (Monash University)

  • Andrew N. Stephens

    (Hudson Institute of Medical Research)

  • Niko Thio

    (Peter MacCallum Cancer Centre)

  • Michelle C. Torres

    (Peter MacCallum Cancer Centre)

  • Nadia Traficante

    (Peter MacCallum Cancer Centre
    The University of Melbourne)

  • Zhongyue Xing

    (Peter MacCallum Cancer Centre)

  • Magnus Zethoven

    (Peter MacCallum Cancer Centre)

  • Yoland C. Antill

    (Cabrini Health
    Frankston Hospital)

  • Clare L. Scott

    (Peter MacCallum Cancer Centre
    Walter and Eliza Hall Institute
    The University of Melbourne
    Royal Melbourne Hospital)

  • Ian G. Campbell

    (Peter MacCallum Cancer Centre
    The University of Melbourne)

  • Kylie L. Gorringe

    (Peter MacCallum Cancer Centre
    The University of Melbourne)

Abstract

Mucinous ovarian carcinoma (MOC) is a unique subtype of ovarian cancer with an uncertain etiology, including whether it genuinely arises at the ovary or is metastatic disease from other organs. In addition, the molecular drivers of invasive progression, high-grade and metastatic disease are poorly defined. We perform genetic analysis of MOC across all histological grades, including benign and borderline mucinous ovarian tumors, and compare these to tumors from other potential extra-ovarian sites of origin. Here we show that MOC is distinct from tumors from other sites and supports a progressive model of evolution from borderline precursors to high-grade invasive MOC. Key drivers of progression identified are TP53 mutation and copy number aberrations, including a notable amplicon on 9p13. High copy number aberration burden is associated with worse prognosis in MOC. Our data conclusively demonstrate that MOC arise from benign and borderline precursors at the ovary and are not extra-ovarian metastases.

Suggested Citation

  • Dane Cheasley & Matthew J. Wakefield & Georgina L. Ryland & Prue E. Allan & Kathryn Alsop & Kaushalya C. Amarasinghe & Sumitra Ananda & Michael S. Anglesio & George Au-Yeung & Maret Böhm & David D. L., 2019. "The molecular origin and taxonomy of mucinous ovarian carcinoma," Nature Communications, Nature, vol. 10(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-11862-x
    DOI: 10.1038/s41467-019-11862-x
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-019-11862-x
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-019-11862-x?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-11862-x. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.